X-RAY INDUCED CNS CHANGES 



TABLE II (Continued) 

 CiMULATivE Effects of X-irradiatiox 



53 



Microscopic 



Glia 



Oligo- Astro- MicTo- 



Non-neural 



Ependyma 



sub- 

 ependyma 



Meninges 



Blood 



vessels 



(I) 



(J) 



(k; 



(L) 



:mi 



(N) 



Scattered areas of Mild Mild 



cellular gliosis in pyknotic, scattered 



sub-pial cortex (PAS) thickening, 



gemestocytic astrocytes. positi\e cellular 



occasional small infarct globules infiltration 



Moderate increase in 

 perivascular connective 

 tissue and blood vessels in 

 hypothalamus, hypertrophy, 

 hyperplasia of endothelium 

 and ad\entitia 



Occasional small Heavy Mild Moderate increase in 



infarct scattered (PAS) scattered perivascular connecti\e 



cellular gliosis in positive thickening, tissue and blood vessels in 



sub-pial cortex globules cellular hypothalamus, hypertrophy, 



infiltration hyperplasia of endotheliimi 

 and adventitia 



Mild increase in 

 peri\ascular connective 

 tissue and blood vessels in 

 hypothalamus, mild hyper- 

 trophy and hyperplasia of 

 endotheliiun and ad\'entitia 



Moderate increase in 

 perivascular connective 

 tissue and blood \-essels in 

 hypothalamus, mild hyper- 

 trophy and hyperplasia of 

 endothelium and ad\entitia 



Mild cellular and Heavy Moderate 



fibrillary gliosis (P.AS) scattered 



around infarcts in positive thickening 



white matter globules 



Moderate increase in 

 perivascular connective 

 tissue and blood vessels in 

 hypothalamus, moderate 

 hypertrophy and hyperplasia of 

 endothelium and adventitia 



Moderate cellular Heavy Moderate 



and fibrillary (PAS) scattered 



gliosis in sub-pial positive thickening, 



cortex, gemestocytic globules cellular 



astrocytes, small infiltration 



infarcts in white 

 matter 



Heavy increase in 

 perivascular connective 

 tissue and blood vessels 

 in hypothalamus, severe 

 hypertrophy and hyperplasia of 

 endothelium and adventitia 



