EFFECTS OF RADIATION ON CNS AND ON BEHAVIOR 



639 



the postexposure deprivation. Only saccharin solution was provided during 

 the 80 minute radiation with either 50 r, 100 r, or 200 r. 



The results for the rats (Fig. 13) show unequivocal depression of sac- 

 charin consumption and preference reversal for the 200 r group. However, 

 we observed no changes, or minimal changes, after 50 r doses. Thus, our 

 results are generally in accord with Garcia-Kimeldorf findings; the differ- 

 ences in the minimal eflfective dose level between their data and ours may 

 be a function of strain of rats or amount of preradiation preference testing. 



LlI 

 LlK 100 



1^ 



if) 

 o< 



O 60 - 



cc a. 

 <0 40 



-,9 



< CO 



12 3 4 

 PRERADIATION DAYS 



12 3 4 

 POSTRADIATION DAYS 



Fig. 13. Radiation-induced saccharin avoidance in rats. 



We have conducted a few exploratory studies on conditioned taste aver- 

 sion with mature rhesus monkeys. Three males were tested on sweetened 

 cheriy Kool-Aid vs. tap water, and the data for one that developed a rela- 

 tively stable preference for the Kool-Aid are presented in Fig. 14. These 

 preradiation preference measures were obtained while the monkey was being 

 rotated in a small cage in the radiation chamber for 45 minutes. During 

 these times, both Kool-Aid and tap water were available to the subject, and 



300 



T — I — I — TTT — I — I T 



6 5 4 3 2 1 30r 90r 150i I 2 3 4 5 

 WEEKS PRE-RAD DAILY EXPOSURES WEEKS POST-RAD 



Fig. 14. Radiation-induced Kool-Aid avoidance by monkeys. 



