113 



Fig. 6. White matter, L-1, 50 days after FO. Note status spongiosiis. Weil stain, 

 X 195. 



gray matter appears early, but this is not common unless 20 ma, or more of 

 FO are used. The delayed, subacute deterioration in spinal cord function is 

 associated with spongy deseneration of white matter. 



Intracerebral Administration 



The injection of 4-6 mg FO i 2-3 ms: FUR) into the sensorimotor cortex 

 of the cat (3-5 mm imder the pial smface through a 26 gauge needle) pro- 

 duces a focal cortical encephalopathy i Kurth (7 al., 1960). A moderate 

 hemiparesis, propriocepti\e deficit, and impaired contact placing reaction 

 appear in the contralateral limbs 3 or 4 days after injection. Focal motor 

 seizures are sometimes seen. The disorder progresses for several davs and 

 then becomes stationary or impro\es slightly. Neural dysfunction persists for 

 several months. A focal electroencephalographic defect is demonstrable in 

 the \icinity of the injection. Normal ihythms are replaced in part by slow 

 wa\es, sharp waxes, and high \oltage spikes ( Figs. 7 and 8 ) . Focal seizure 

 actixity appears spontaneously or may be provoked by joint movement or 

 skin pinching of the contralateral limbs. Biochemical studies ha\e rexealed a 

 high incorporation of FO-2-C" into RNA near the injection site. Indeed, 

 there is a close correlation between the presence of electroencephalogiaphic 

 abnormalities and a high uptake of FO into RNA of affected cortex. 



The introduction of FO or FUR into the temporal lobe of cats may pro- 

 duce alterations in personality and epileptiform seizures (Koenig ct al., 

 1960bi. Some animals become withdrawn, imfriendly. hostile, and e\en 

 aggressive, with periods of confusion, stupor, and other disturbances of be- 

 havior indicative of temporal lobe seizures. Sometimes the contralateral pupil 



