NUCLEIC ACID ANTIMETABOLITES AND CNS 



119 



Summary > ? .• < 



Intrathecal administration of the fluorinated pyrimidines, FO. FUR, and 

 FCR, results in interesting neurologic disorders, the nature of which depends 

 on the injection site. Myelopathy, rhombencephalopathy, and cortical en- 

 cephalopathy are produced by the intralumbar, intracisternal, and intracere- 

 bral routes, respectively. An asymptomatic "incubation'' period precedes the 

 appearance of neural dysfunction. Signs of neuronal hyperirritability ap{3ear 





*^«• 



J ■• 





* D FO HYPERREFLEXIC P.\RAPARESIS 



'■#* 



7 D FO in'PERREFLEXIC PARAPARESIS 7 D FO HYPOREFLEXIC PARAPLEGIA 



Fig. 13. .Autoradiographs of L-7 segment showing uptake of methionine-S"^ into 

 neuronal protein. Note reduction in blackening over experimental neurons three and 

 seven days after FO, most marked in animal with hyporeflexic paraplegia. X 700. 



