HISTOPATHOLOGY OF CNS RADIATION 



181 







Fig. 9. Luntjitudinal station ol spinal ( urd lo sliow the junction of a zone of total 

 radiation necrosis with surviving spinal cord tissue. Weil's method X40. Dosage 

 54,500 r x-radiation given in 23 days. On the day after completon of radiation, the 

 monkey developed paraparesis which progressed to complete paraplegia in a few 

 hours. Sacrifice 1 week after radiation. .Autopsy showed a constriction in the spinal 

 cord at the 7th and 8th thoracic segments. See also Fig. 10. 



noid space have been encountered. Other necroses are smaller and in\olve 

 localized regions of white matter. 



When repair begins to take place after some months, the collagen pro- 

 liferates long before the inhibition of astrocytes has ceased. Compound 

 granular corpuscles make their first appearance at about the time that 

 production of collagen is resumed. 



The result of these alterations in the growth capacities of the cells usually 

 involved in repair of central nervous system lesions is a localized, walled-ofT 



