MORPHOLOGICAL EFFECT OF X-RAYS TO THE CNS 215 



Fig. 4. Plasmatic mhltration and erythrodiapedesis into the tissue in an area of 

 disintegration of the white matter from the same case as Fig. 3. van Gieson. 



for the fact that in routine in\estiiiations of single cases, no morphologic 

 changes may be observed, although the animals are paralyzed. 



In the second series, transformation of the tissue debris into sudanophilic 

 material could not be observed, although in many cases the clinical symp- 

 toms indicated that morpholo2,ic changes were 3 to 4 weeks old. 



In addition to these experiments on the spinal cord of rabbits, the brains 

 of approximately 100 Syrian hamsters were irradiated to examine the effect 

 of a high and intensi\e single x-ray dose using a special Siemens x-ray 

 machine with a beryllium tube. The animals were fixed on a small table 

 (Fig. 6 I, and the whole body was covered v,ith a half tube of lead, except 

 for the head which was held in position by two metal clips. A small brass 

 cylinder, 1 cm in diameter, was used for local application of x-rays and 



