358 ANDERSSON, LARSSON, LEKSELL, MAIR, REXED AND SOURANDER 



Summary 



For the past several years experiments were carried out to determine the 

 local efTect on the central nervous system of his,h energy protons. The Irra- 

 diations were performed on rabbits and goats with a 185 Mev proton beam 

 from the 230 cm synchrocyclotron at Uppsala. The experiments have shown 

 that It Is possible with high energy protons to produce small well circum- 

 scribed cerebral lesions at a desired site in the brain without damaging the 

 surrounding tissue. The Importance of performing long-term experiments to 

 determine the late effects of high energy protons on the brain is stressed. 



References 



Anderson, A., Garcia, J., Henry, J., Riggs, C, Roberts, J. E., Thorell, B., and Tobias, 



C. A. 1957. Pituitary and hypothalamic lesions produced by high-energy deutcrons 



and protons. Radiation Research 7, 299. 

 Arnold, A., and Bailey, P. 1954. Alterations in the gHal cells following irradiation of 



the brain in primates. A.M. A. Pathol. 57, 383-391. 

 -Arnold, A., Bailey, P., and Laughlin, J. S. 1954. Effects of betatron radiations on the 



brain of primates. Neurology 4, 165-178. 

 Berg, N. O., and Lindgren, M. 1958. Time-dose relationship and morphology of de- 

 layed radiation lesions of the brain in rabbits. Acta Radiol. Suppl. 167, 1-118. 

 Larsson, B. 1960. Blood vessel changes following local irradiation of the brain with 



high-energy protons. Acta Soc. Med. U psaliensis 65, 61-71. 

 Larsson, B., Leksell, L., Rexed, B., Sourander, P., Mair, W., and Andersson, B. 1958. 



The high-energy proton beam as a neurosurgical tool. Nature 182, 1222-1223. 

 Larsson, B., Leksell, L., Rexed, B., and Sourander, P. 1959. Effect of high energy 



protons on the sj)inal cord. Acta Radiol. 51, 52-64. 

 Leksell, L. 1951. The stereotaxic method and radiosurgery of the brain. Acta Chir. 



Scand. 102, 316-319. 

 Leksell, L. 1957. Gczielte Hirnoperationen. In "flandbuch der Neurochirurgie" (H. 



Olivecrona and W. Tonnis, eds.). Vol. VI, pp. 178-199. Springer, Berlin. 

 Leksell, L., Larrson, B., Andersson, B., Rexed, B., Sourander, P., and Mair, W. 1960. 



Restricted radio-lesions in the depth of the brain produced by a beam of high 



energy protons. Acta Radiol. 54, 251-264. 

 Malis, L. J., Loevinger, R., Kruger, L., and Rose, J. E. 1957. Production of laminar 



lesions in the cerebral cortex by heavy ionizing particles. Science 126, 302-303. 

 Rexed, B., Mair, W., Sourander, P., Larsson, B., and Leksell, L. 1960. Effect of high 



energy protons on the brain of the rabbit. Acta Radiol., 53, 289-299. 

 Russell, D. S., Wilson, C. W., and Tansley, K. 1949. Experimental radionecrosis of 



the brain in rabbits. /. Neurol. Neurosurg. Psychiat. 12, 187-195. 

 Tobias, C. A., Anger, H. O., and Lawrence, J. H. 1952. Radiological use of high 



energy deuterons and alpha particles. Aryi. J. Roentgenol. Radium Therapy Nuclear 



Med. 67, 1-27. 

 Zeman, W., Curtis, H. J., Gebhard, E. L., and Haymaker, W. 1959. Tolerance of 



mouse-brain tissue to high energy deuterons. Science 130, 1760-1761. 



