CHEMICAL CHAxNGES IN IRRADIATED NERVE CELLS 431 



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Fig. 2. 1 mm beam: Ib.bUU rad. 7 days survival. Hippocampus. Note complete 

 tissue necrosis with cavity formation, hemorrhages in molecular layers and beginning 

 formation of compound granular corpuscles. PTAH. 



pathogenic mechanisms of radiation damage of the brain tissue obser\ed by 

 Schiimmeheder (1959). namely direct radiogenic neive cell necrosis. 



Preliminary experiments were designed to elucidate some chemical events 

 incident to this necrosis. 



Methods 



Carworth CF, female mice. 6 to 7 weeks old, weighing 25 to 35 gm, were 

 irradiated with different doses and beams and were sacrificed after 1, 2, 3, 

 4. 5. and 7 days. The animals w^ere anesthetized and the brains were fixed 

 by in situ perfusion with Heidenhain's Susa fluid. After being embedded in 

 paraffin, the brains were cut in serial sections, even- second section being 



