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FARR ET AL. 



Fig. 1A. Patient 5972 r. Whole brain section (myelin stain) showing destruction 

 of most of the right temporal lobe in which the tumor was located. The areas not 

 affected by the tumor, but receiving the maximimi irradiation, show intact myelin. 



maximum neutron intensity, destructive effects to the neoplastic area occurred. 

 In the other cases, no alteration in the neoplasms, attributable to neutron 

 capture therapy, could be established. Microscopic studies of nontumorous 

 and adjacent neuronal structures in all these cases, carried out with various 

 staining techniques, gave no suggestion that damage had been done to the 

 nonneoplastic central nervous system structures by the irradiation procedure. 

 A typical section is shown in Fig. lA. By one set of assumptions, in which a 

 uniform neutron exposure is postulated to permit simple calculation, the 

 computed dose from tissue-component capture gammas alone (administered 

 to the cerebral cortex) ranged from 78 to 1128 rad in these patients. These 

 and other calculations were made by Dr. J. S. Robertson of our department. 

 Effects due solely to thermal neutron exposure were studied in a man, aged 

 53, with glioblastoma multiforme in the right frontoparietal region, who 

 was admitted for neutron capture therapy. He had had operative removal 

 of part of the lesion and no subsequent x-ray therapy. Due to a technical 

 difficulty not appreciated or known at the moment, the patient did not 

 receive the injected sodium pentaborate into the carotid artery; thus, when 



