448 



FARR ET AL. 



Fig. 2. Whole brain section of case 8180 r at the level of the genu of the corpus 

 callossum, showing demyelinization of the right temporal lobe and the insular region 

 of the same side in the vicinity of the tumor. The frontal lobe has a normal myelin 

 content. 



appears completely normal. In the same section the cerebellum may be seen 

 with an entirely normal-appearinsi pattern of myelin. The Nissl substance 

 and the neurofibrils show no alteration in a section taken from the cortical 

 reo'ion receiving' the maximum neutron exposine f Fitj. 4) . 



Effects on nonneiuonal structures were studied in one patient receiving 

 neutron capture therapy with high exposure achie\ed in 200 sec. A man, 

 aged 44, who had a left frontal craniotomy for oligodendroblastoma, was 

 admitted after x-ray treatment following surgery. The surgical wound was 

 infected, and there was a brain abscess. Following treatment for the latter, 

 it was observed that there was a recurrent deep lying neoplasm in the left 

 frontal lobe. He was given 35 mg B^" per kg body weight in the antecubital 

 vein. At 31 minutes after the boron infusion, the left frontal area was irradi- 

 ated for 200 sec with 1.73 X 10'' thermal neutrons per sc|uare cm at the 

 cortical level. Death occurred 30 days after neutron capture therapy. 



Figure 5 shows the whole brain as removed at autopsy. The defect in the 

 frontal lobe indicates the area of original operative interference and the site 

 of irradiation with thermal neutrons. Fioiue 6 is a coronal section 3 cm from 



