(•iii;mi('al sTurcTriiK am) hiolookal activity 



SoO 



H Hj 



HC C CH, 



HC C ^C-CH, 



c c 



H II 







h/ V N 



H 

 C-CH, 



HC, 



V"- 



XXX 



The activity of 2-inethyl-l-naphthyIamine (XXXI) presumably indi- 

 cates its conversion to 2-methyl-l-naphthol in the body. That this trans- 

 formation must be somewhat inefficient is indicated by the fact that it has 

 only 20% of the potency of the latter compound. On the other hand, the 

 2-methyl-4-aminonaphthol (XXXII) possesses a potency almost as great as 

 that of methylnaphthoquinone. The formation of the methylnaphtho- 

 quinone follows the formation of the quinonamine. 



H H 



HC. C CCH3 



\ r 



H I 



NH, 



H T' 



„/V\h 



HC. C^ .CCH, 



w 



H I 



OH 



ipntr 



Tcmt 



