234 



THE ACTINOMYCETES, Vol. I 



FiGURK .^'.1. First cxixTiniciit in which the efft'ct of .streptomyfin upon the giuwlii of M . tuberculosis 



M-as demoiistnitod (l{opn)(hK-('d from: Schalz, A. and Waksman, S. A. Pr.)c See Exptl Biol Med 57: 

 246, 1044). 



Streptomycin was detected in tli(> solntion imuni was reached between 48 and GO hours 

 during the first 12 houis of ^lowtfi of the of growth. After this, a decHne in the strep- 

 organism. The foiinatioii of the antibiotic tomycin coiilent of the sohition occurred. 

 mcreased steacUly from tiien on until a max- This decrease continued mitil after al)out 9() 



