Xll CONTENTS 



PART II 

 MECHANISM OF ANTIBODY FORMATION 



Page 



The Factors Controlling the Production and Persistence of Anti- 

 body 49 



1 . The Relation of the Specificities of Host Enzymes to the Anti- 

 genicity of Substances Foreign to the Species of the Host 49 



2. An Inquiry into the Nature of Factors Controlling the Balance 



of Antigen and Antibody During Immunization .... 61 



Theories on the Site of Antibody Formation 67 



1. The Lymphocytic Theory 67 



a. The Hormonal Control of Anamnestic Response and Lym- 

 phocytes 70 



b. Findings Contrary to the Theory of the Hormonal Control 



of the Release and Fabrication of Antibody 72 



2. The Reticulo-Endothelial Theory 72 



a. The Theory of Sabin 72 



b. Plasma Cells as Antibody Producers 73 



Theories on the Mechanism of Antibody Formation .... 77 



1. An Introductory Comment on the Antigenic Specificity of 

 Proteins 78 



2. The Role of Determinant Groups on the Antigenic Specificity 



of Conjugated Proteins 84 



3. Mechanism of Antibody Formation 86 



a. The Theory of Breinl and Haurowitz 86 



b. The Theory of Mudd 86 



c. The Theory of Alexander 87 



d. The Theory of Pauling 87 



4. The Concept of Catalysis as Implied by the Above Theories 



on the Mechanism of Antibody Formation 89 



5. Theory of Burnet et al. of Antibody Formation and Adaptive 

 Enzyme Process 90 



a. The Premises of the Theory of Burnet et al 90 



b. Consideration of the Adaptive Enzyme Concept with Re- 

 spect to Antibody Production 95 



c. Adaptive Enzymes— A Consideration of Facts and Assump- 

 tions 96 



d. Consideration of the Primary Role of Antigen in Antibody 

 Production as Postulated by Burnet, et al 100 



e. Consideration of Antigens as Toxic Agents Causing the 

 Mutation of Globulin Synthesizing Enzyme System . 102 



6. On Jordan's Autocatalytic Theory of Antibody Formation 104 



