XVI CONTENTS 



Page 



a. Immunity Against Proteinases of Various Bacteria 258 



b. Antibody Against Streptococcal Proteinase 259 



c. Differences of the Proteinases of CI. Sporogenes and CI. 

 Histolyticum and the Specificity of the Anti-Proteinases . 260 



d. The Abihty and Inabihty of Normal Serum "Trypsin-Inhib- 

 itor" and Raw Egg White to Inhibit the Proteinases of 

 Pathogenic and Non-Pathogenic Bacteria 262 



F. Fibrinolysis 263 



1 . Serum Proteinase as Fibrinolytic Enzyme and the Role of Bac- 

 terial Fibrinolytic Factor 263 



a. Comment on Nomenclature 263 



b. Digestion Products of Fibrin and Fibrinogen .... 264 



c. Distribution of Bacterial Fibrinolytic Factor 266 



d. Fibrinolytic Factor and Bacterial Invasiveness .... 269 



e. Antibody to Fibrinolytic Factor 269 



2. Postulates on the Role of the Bacterial Fibrinolytic Factor . 271 



a. Comments on the Possible Nature of the Role of Bacterial 

 Fibrinolytic Factor 275 



b. A Suggestion as to the Possible Lipolytic Role of Strepto- 

 coccal Factor 278 



G. Mechanism of Fibrin and Milk Clot Formation 278 



1 . Enzymes Responsible for the Formation of Plasma Clot . . 278 



a. Comment on the Use of the Term Coagulation .... 278 



b. Factors Responsible for the Formation of Plasma Clot . 279 



c. Enzyme Nature of Thrombin 280 



d. Conversion of Fibrinogen into Fibrin 280 



2. Chemical Reactions Involving -S-S- Linkages in the Conver- 

 sion of Fibrinogen to Fibrin 282 



3. Antibody Against Thrombin. Neutralization of Thrombin 



of Rabbit Serum by Anti-Rabbit Guinea Pig Immune Serum 285 



4. Antibody Against the Plasma Clotting Enzymes of Snake 

 Venom 289 



a. Enzymic Nature of Blood Clotting Activity of Snake 

 Venoms 289 



b. The Clotting of Fibrinogen by Snake Venoms .... 289 



c. The Activation of Prothrombin to Thrombin by Snake 

 Venoms 290 



d. Anti-Thrombin, Anti-Proteolytic, and Anri-Necrotic Acrivi- 



ties of Antivenin 291 



5. Staphylococcal and Other Bacterial Factors in Fibrin Clot 

 Formation 295 



a. Distribution of Plasma Clotting Factor among Bacteria 295 



b. Anti-Clotting Factor 295 



