CONTENTS XVll 



Page 



c. The Role of Bacterial Clotting Factor in Phagocytosis and 

 Infection 296 



d. Comment on the Nature of the Staphylococcal Clotting 

 Factor 298 



e. "Activation" of the Staphylococcal Clotting Factor . 299 



f. Properties of Clotting Factor and Activator Substance and 

 Their Possible Role in Fibrin Clot Formation .... 300 



6. Antibody Against Rennins 303 



a. Certain Properties of Rennin 303 



b. Mechanism of Milk Clotting 304 



c. Milk and Plasma Clots Compared 304 



d. Antibody Against Animal Rennin 304 



e. Antibody Against Plant Rennin 306 



H. Enzymatic and Pharmacological Activities of Hemolytic Sub- 

 stances 307 



1. Hemolytic Lysolecithin Derived by the Action of Snake 

 Venom Lecithinase 307 



a. Discovery of Hemolytic Lecithinase and Its Neutralization 



by Antivenin 308 



b. Physiological Consequences of the Action of Lysolecithin 312 



2. Ricin 314 



a. Chemical Nature of Ricin 314 



b. Inhibition of Lecithinase and Hemolytic Activities of Ricin 



by Anti-Ricin Immune Serum 315 



3. Bacterial Hemolysins 316 



a. Hemolytic, Dermonecrotic and Lethal Activities of Staphy- 

 lococcal Toxin 317 



b. The Relation of the Lipase Activity of Staphylococci to 

 Hemolysis 318 



c. Hemolytic Toxin of Clostridium Septicum 319 



4. Pneumococcal Hemolysin 319 



a. Number of Pneumococcal Hemolysin Molecules Required 



to Hemolyze One Red Blood Cell 323 



b. A Study of the Antipneumolysin Titer of the Sera of Pneu- 

 monia Patients 324 



5. Streptococcal Hemolysin 324 



a. Streptolysin O 326 



b. Probable Enzymic Nature of Bacterial Hemolysins 328 



I. Antibody Against Nucleases, Urease and Penicillinase .' 329 



1. Antibody Against Ribonucleases 329 



a. Liberation of Adenyl Compounds from Perfused Organs 



Treated with Cobra Venom 329 



