XX CONTENTS 



Page 



d. The Function of Antihistamine Substances and Their Phar- 

 macological Action 411 



e. Histamine and Antihistaminic Substances 412 



f. A Comparison of the Syndromes of Histamine and Ana- 

 phylactic Shock 414 



6. Metabolic Changes in Shock 414 



7. Acetylcholine in Anaphylactic Shock 415 



a. Destruction and Synthesis of Acetylcholine 416 



b. "Muscarinic" and "Nicotinic" Actions of Acetylcholine 416 



c. Antagonists to Acetylcholine 417 



d. The Role of Acetylcholine on the Effector Organs . .417 



e. Effects of Administered Acetylcholine in Man . .418 



f. In Vitro Action of Acetylcholine on Muscle Contraction 419 



g. Role of Acetylcholine in Anaphylactic Shock . .421 

 h. Liberation of Acetylcholine in Anaphylactic Shock . 422 

 i. Experiments Cited to Support the Acetylcholine Theory of 



Anaphylaxis 424 



j. Summary of Evidence in Favor of Acetylcholine Theory . 426 



8. Metabolic Changes in Anaphylactic Shock 427 



a. Liberation of Potassium 427 



b. Potassium-Calcium Antagonism 428 



c. Acidosis in Anaphylactic, Histamine, and Peptone Shock 429 



d. Metabolic Factors in Anoxia 430 



9. Theories on the Liberation and the Role of Proteinases in 

 Anaphylactic Shock 432 



10. The Question of Proteolysis and Release of Histamine in 



Shock Produced by Proteolytic Enzymes and in Anaphylaxis 435 



References 445 



Author Index 509 



Subject Index 521 



