Table XIV 



d. The Ability and Inability of Normal Serum "Trypsin-Inhibi- 

 tor" and Raw Egg White to Inhibit the Proteinases of Pathogenic 

 and Non-Pathogenic Bacteria. 



Bacterial strains 



CI. histolyticum, 

 smooth 



CI. histolyticum, 



rough 

 CI. sporogenes 



CI. aerofetidum 

 CI. botulinum, 

 types A & B 



CI. fallax 



CI. oedematis-maligni 



CI. putrificum 

 CI. bifermentans 

 CI. welchii 



CI. sordelli 



pyocyaneus 



B. prodigiosus 

 B. mesentericus 

 Trypsin 



Inhibition by: 



Normal 

 serum 







+ + 



+ 4- 



+ + 

 + + 



+ + 



+ + 





 



+ + 



+ + 

 + + 

 + + 



Raw egg 

 white 



+ + 



+ + 



Action 

 delayed 



Pathogenicity 



Appears in gangrenous process 

 of man; guinea pig, rabbit and 

 mouse are susceptible. 



Non-pathogenic. 



Non-pathogenic, no exotoxin 

 produced. 



Non-pathogenic. 



Does not multiply in the body, 

 acts entirely by its powerful 

 toxin produced in vitro. 



Pathogenic for guinea pig, 

 mouse when freshly isolated, 

 but pathogenicity rapidly dis- 

 appears even in dry form. 



Pathogenic: guinea pig, mice, 

 rabbits; causes gas gangrene 

 in man; potent toxin pro- 

 ducer. 



Non-pathogenic. 



Non-pathogenic. 



Chief agent in causing gas gan- 

 grene in man and animals. 



Pathogenic: found in gas gan- 

 grene of man and sheep; rab- 

 bit, guinea pig and mouse 

 susceptible. 



Low pathogenicity in man; sub- 

 cutaneous injection gives rise 

 to fever and local abscess in 

 rabbits. 



Non-pathogenic. 



Non-pathogenic. 



Kills rabbits injected intrave- 

 nously. 



-\ — |- ^ inhibition ^ no inhibition = data lacking. 



*Pozerski and Guelin (1938a) reported that raw egg white inhibited the 

 hydrolysis of gelatin by the proteinase of this organism. However, coagulated 

 serum, which contains the thermostable "trypsin-inhibitor," is hydrolyzed by 

 this organism. 



