ANTIBODIES AGAINST RESPIRATORY ENZYMES 



373 



Glucose — 6 — phosphate 



jr 

 CH3C-C00H — y 



n 

 O 



Pyruvic acid 



+CO2 -CO2 

 HOOC-CH2 



0=6-C00H 



Oxalacetic acid 



+2H — 2H 



HOOC— CH2 



HO-C-COOH 

 I 

 H 



Malic acid 



-H2O 

 HOOC-C-H 



+H2O 



H— C— COOH 



Fumaric acid* 



-I-H3PO4 



-H3PO4 



CH3-COOH 



Acetic acid 



+ 

 HOOC-CH 



HOC-COOH 

 (enoO-Oxalacetic acid 



-H2O 



HOOC-CH 



C-COOH 



(bnaCOOH 

 cis-Aconitic acid 



+H2O -H2O 



hooc-choh 

 6hcooh 



6h2 



iooH 



Iso-citric acid 



> 



% 



fo 



HOOC-CH2 



HO-(b-COOH 



(iooH 



Citric acid 



HOOC-CH-O-PO3H2 



H2C-COOH 

 Phosphomalic acid 



— 2H 



HOOC-C-O-PO3H2 



H -C-COOH 

 Phospho-oxalacetic acid 



— CO2 +CO2 



HOOC-C-O-PO3H2 



II 

 CH2 

 Phosphopyruvic acid 



* Fumaric acid 



— 2H +2H 



CH2COOH 



CHCOOH 



COCOOH 

 Oxalsuccinic acid 



-CO, 



+CO, 



HOOC-C=0 



iH2 

 iH2 

 600H 



o— Ketoglutaric acid 

 +2H HOOC-CH, 



-2H 



H2C-COOH 

 Succinic acid. 



intermediates, etc., constant metamorphoses; the most recent view favors Krebs' 

 original scheme. (For the latest review see S. Ochoa, Phys. Revs., 31:56-106, 1951.) 



