430 



IMMUNO-CATALYSIS 



volume of oxygen consumed before, during and in the post-shock 

 period of shocks produced by histamine and peptone. They obtained 

 the following table of results: 



Table XXIV 



The results show that histamine (and peptone) shock causes an in- 

 crease in the lactic acid content of the muscle. When associated with 

 muscular work, shock caused a greater accumulation of lactic acid. 



The measurement of oxygen consumption and carbon dioxide evo- 

 lution during histamine and peptone shock showed a decrease of 

 oxygen consumption, and an accumulation of lactic acid in the muscles 

 of the shocked animals. (Danielopolu reported that there is acidosis 

 in anaphylactic shock, and alkalosis in histamine shock.) This effect 

 was due to a circulatory disturbance. Following the shock period, the 

 surviving animals consumed more oxygen than they did before the 

 shock. When the crisis was over and normal conditions were restored, 

 the oxygen consumption resumed the normal rate. The increased 

 oxygen consumption following the shock period was apparently due 

 to the oxidation of accumulated lactic acid and other products. 



d. Metabolic Factors in Anoxia. In connection with the above 

 cited increase in muscle lactic acid, it is of interest to recall the refer- 

 ence previously made with regard to the increased urinary creatine, 

 uric acid and urea ammonia (Miller, 1940) in anaphylactic shock. In 



