SUBJECT 



lactic acid, increase in blood, 430 

 mechanism of, a recapitulation, 



441-443 

 metabolic changes in, 402, 407, 



414-415, 430-432 

 muscle contraction, depression in, 



420 

 physiological changes in, 407 

 potassium, liberation in, 427-428 



calcium antagonism in, 428-429 

 proteolysis in, 435-441 

 shock by, 399 



allergy, as a form of, 399 

 proteinases, role in, 432-441 

 sjTmptoms in guinea pig, dog, rabbit, 



401 

 syndromes, compared with those of 



histamine, 414 

 urea, uric acid, increase in urine, 



430 

 Anoxia 



metabolic factors in, 430—432 

 Anti-amboceptor, 133 

 Anti-antibodies, 122, 131-141 

 Anti-enzymes (Antibody against en- 

 zymes), 39, 175 (see also 



Enzymes) 

 amylase, 187, 215, 220-223 

 catalase, 377-378 

 carbohydrases, 217 

 carboxylase, 377 

 collagenase, 359-361 

 dehydrogenase, d-3-phosphoglycer- 



aldehyde, 385-388 

 emulsin, 214-217 

 flavoprotein, comment on, 379 

 hexokinase, 382-385 

 hyaluronidase, 247-249, 360 

 inulase, 217 

 invertase, 224 

 lecithinase, 212, 308-312, 339- 



352, 361 

 luciferase, 396-397 

 lysozyme, 230-231 

 papain, 253-255 



INDEX 



523 



penicillinase, 213, 332-335 

 phosphatase, comment on, 390-393 

 polysaccharidases, 230 

 proteinases, 249-261, 291-294 

 reductase, pyruvic, 381 

 rennins, 304-307 

 thrombin, 285-289, 291-294 

 trypsin, 178, 249-253 

 tyrosinase, 393-395 

 urease, 39, 212, 331-332 

 Anti-pneumolysin, 324 

 Anti-streptolysin, 269-270 

 Anti-venom, snake, 290-294, 308 

 Antibody (see also Antitoxin, Anti- 

 enzyme, Agglutinins) 

 acylation of amino groups, 109 

 antigen, mechanism of the reaction 

 with, 158, 160 

 cell complex, 62-63 

 comparison with enzyme-substrate 

 reaction, 158, 160, 204- 

 213 

 complex, use as antigen, 136, 206 



comment on, 136 

 molecular ratios, 210 

 as racemization, 130-131 

 equilibrium during immuniza- 

 tion, 61—63 

 cleavage products, specificity of, 



118-120 

 coincidence with antigen in vivo, 



64-67 

 components of, V4 and M size, 118- 



121 

 destruction by pepsin, 9 

 digestion products, specificity of, 



118-120 

 enzyme (antigen), as specific in- 

 hibitor of, 143, 157, 

 159-160 

 failure to manufacture in vitro, 116 

 formaldehyde, effect on the activity 



of, 123-124 

 globulin, as modified, 8, 9, 50 

 iso- (antibodies), 7, 46 



