524 



IMMUNO-CATALYSIS 



Antibody— (Cont'd) 



metabolism of, 51, 52-57 



as mirror image of antigen, 130 



pneumococcal polysaccharide, 123 



isoelectric point of, 123 

 polysaccharides in, 130-131 



as seat of serological specificity, 

 130-131 

 production of, 8, 25, 49, 63, 67 

 action of pilocarpin on, 31 

 adaptive enzyme concept, 90-92 



a critique of, 92-104 

 autocatalytic theory of, 104-105 

 catalysis in, concept implied in, 



90 

 hormonal control of, 70-72 

 lymphocytes as the site of, 67—72, 



76, 77 

 lymphatic theory of, 67-72 

 mechanism, theories regarding, 



77-105 

 microphages in, 68 

 nucleic acid, metabolism in, 76 

 persistence of, 49 

 plasma cells as site of, 72-77 

 reactive groups in, 123-125, 



134-135 

 reticulo-endothelial theory of, 



72-77 

 role of catalysts in, 10 

 speed of, 63 

 proteolytic enzymes, action on, 9, 



119 

 synthesis, spatial configuration in, 



132 

 typhoid "H" and "O," 120 

 specificity of, 121 

 Antigen(s) (see also Toxins, Enzymes, 

 Polysaccharides, Agglu- 

 tinogen, etc.^ 

 absence in antibody, 35, 36 

 antibody reaction 



cell-injury as result of, 400, 439, 

 440 



complex, use as antigen, 136, 206 



comment on, 136 

 enzyme-substrate reaction, com- 

 parison with, 158, 159- 

 160, 204-213 

 equilibrium during immuniza- 

 tion, 61-63 

 lipids, combination with, 439 

 consequences of, 439-440 

 mechanism of, 158 

 molecular ratios, 210 

 pathology, 399 

 pH, effect on, 192-195 

 racemization, considered as, 130- 

 131 

 azo-proteins, 34, 56, 72-73, 84-86, 



148-153, 189 

 as biocatalyst, 7 

 characteristics common to, 25, 38, 



42 

 coenzyme, collation as, 116-118 

 coincidence with antibody in the 



host, 64-67 

 conjugated (protein), 34, 46-47, 

 54, 72-73, 117-118, 148- 

 158, 189 

 definition of, 143 

 determinant groups in, 85-86 

 digestion products, specificity of, 



114 

 as enzymes, a collation, 27-45, 47, 



116-118, 144-159 

 hormones as, 144 

 host enzymes, relative resistance to, 



52-61 

 "marked," 36-38, 44 

 minimal effective quantity, 30-35 

 as mirror image of antibody, 1 30 

 mutagenic agents, consideration as, 



102-104 

 specific soluble (see Polysaccha- 

 rides) 

 Antihistamine substances, 411-413 

 allergy, effect on, 411 

 histamine, antagonism to, 411-412 



