SUBJECT 



proteolytic action of toxin of, 



256, 260-263, 349 

 e-prototoxin, comment on, 341 



(footnote) 

 succinoxidase (tissue), inhibition 

 by toxin of, 352-354 

 neutralization by o-antitoxin, 

 354-355 

 Clotting, fibrin formation 



anti-clotting factors, elaborated by: 

 Clostridium histoylticum, 

 novyi, se^pticum, sporo- 

 genes, welchii, Entero- 

 cocci, E. coli, Pneumo- 

 cocci, Pseudomonas -pyo- 

 cyaneus, Streptococcus 

 viridans, 295-296 

 differentiation from coagulation, 



278-279 

 factors in, bacterial; Clostridium 

 histolyticum , novyi, septi- 

 cum, sordelli, sporogenes, 

 welchii, Staphylococctis 

 aureus, alhus, 295 

 fibrinogen, plasma, 273, 275 



thiol groups, oxidation as cause of 

 clotting, 282-285 

 host specificity in, in relation to in- 

 fection, 296-298 

 milk, 114, 303-304 

 mechanism of, 304 



comparison with plasma clot- 

 ting, 304 

 pepsin, 114 



inhibition of, 114 

 plasma, 278-303 



oxidative process as cause of clot- 

 ting, 282-285 

 snake venom, 289-294 

 pathology of, 291-294 

 staphylococcal factors in, 295-303 

 "activation" of, 299-300 

 comment on the nature of, 298- 

 299 



INDEX 



529 



distribution of, 295 

 mechanism of the action of, 302- 



303 

 properties of, 300-302 

 phagocytosis, inhibition of, 296- 

 298 

 Collagen 



bacterial enzymes, solubilization by, 



359 

 properties, chemical, physical, 359- 



360 

 proteinases, resistance to, 359 

 Collagenase 



anti-collagenase, 360-361 

 gas-gangrene, CI. welchii, 359-361 

 as toxin, 360 

 Configurations, spatial 

 a-, P-, d-, 1-, 131 



antigenic specificity of, 132 

 enzyme reactions, role in, 144- 



159 

 immune reactions, role in, 144- 

 159 

 Creatine, phospho-, 419 



increase in urine in cell injury, 436 

 Curare, as antagonist to acetylcholine, 



417 

 Cyanide, hydrogen, 127 

 Cysteine, 80 



role in fibrin formation, 50 

 Cytochrome(s), 83 

 a, h, c, 106, 364, 431 

 oxidase, 29, 83, 364, 431 

 peroxidase, 83, 364 

 c reductase, 364 

 Cytoplasmic changes, 1 00 



Dehydrogenases 



alcohol, crystalline, 26, 371 

 cozymase I and II, 364, 369, 370, 



377 

 dihydroxyacetonephosphate, 366, 



370 



