SUBJECT INDEX 



535 



epinephrine, eflFect on the Hberation 



of, 412 

 histidine as source of, 410 



formation from, by bacterial ac- 

 tion, 410 

 liberation (by the action of): 

 aliphatic amines, 438 

 antigen-antibody reaction, as 



cause of, 399, 400 

 CI. ■welchii toxins, 355—357 

 cobra venom, 313-314, 437 

 lysolecithin, 312-313, 437 

 papain action, 405 

 peptone shock, 403 

 proteinases, 405-406, 432-441 

 pyridinium salts, 438 

 staphylococcal toxin, 317 

 muscle contraction, depressive ac- 

 tion on, 420 

 origin, histidine as precursor of, 



409-410 

 pharmacological action of, 408 

 shock, 407-408 



acidosis in, 429-430 

 chemical changes, 414-415 

 lactic acid, increase in, 430 

 oxygen uptake, decrease in, 428 

 syndrome, compared with those of 

 anaphylaxis, 414 

 Hormones, as antigens, 144 

 Horse serum 



antihorse chicken serum, 65-66 

 antihorse rabbit serum, 66 

 Hyaluronic acids, 234, 238, 245 

 hyaluronidase, mechanism of hy- 

 drolysis by, 238-239 

 Hyaluronidase, permeability factor, 

 231-249 

 activity, measurements of, 239-241 

 discovery, 231 

 distribution, 232, 241 



among bacteria, 232, 234, 235, 

 236, 237, 241, 243, 351 

 enzymatic nature, 233-237 

 fertilization, effect on, 246 



hyaluronic acid, as substrate of, 234 

 inhibition of, 246-247 



anti-invasin, chondroitin sulfate, 

 heparin, mucin, salicylate, 

 247 

 by anti-hyaluronidase antibody, 

 247-249 

 infected tissue, presence in, 245 

 infections, relation to, 232 

 mechanism of action, 237-239 

 polysaccharides, action of, 237 

 production during bacterial growth, 



243-244 

 virulence (bacterial), relation to, 

 241-244 

 Hydrocyanic acid, 127 

 Hydrogen bonding, 109, 111, 204- 



205, 303 

 Hydrogen ion, 15 



hydrolysis by, 21 

 Hydrogenylase, 98 

 Hydrolysis, acid catalyzed, 21 

 Hydronium ion, 14 

 Hydroxylion, 15 



hydrolysis by, 21 

 Hydroxybutyric acid oxidation, 164 

 Hjiperglobulinemia, 73, 74 



during immunization, 74, 103 

 Hypoproteinemia, 52 



Immune reaction, compared with en- 

 zyme reaction, 144-159 



Immunity 



as biocatalytic process, 143 

 hyperglobulinemia in, 73, 74, 103 

 persistence of, 92 



Immunological "paralysis," 60-61 



Infection 



fibrinolysis, relation to, 266-270 

 plasma clotting, relation to, 296- 

 298 



Influenza, hemophilus, 98 



Insulin, acylation of, 199 



