Thrombin, 276, 279, 280 



antibody against, 285-289, 291- 



294 

 coenzyme, vitamin K as, 284-285 

 enzyme nature of, 280 

 fibrinogen -> fibrin, 279, 283 



oxidative role in, 285 

 proteolytic activity, absence of, 276 

 prothrombin, conversion by snake 

 venom into, 290-291 

 conversion by trypsin, 279, 289 

 serum proteinase, resistance to, 276 

 snake venom, presence in, 289—295 

 antibody against, 289-295 

 conversion of prothrombin into, 

 290-291 

 Thrombokinase, 280, 299, 300 

 Thromboplastin, 275, 276, 279, 299 



properties of, 300-302 

 Thymus, as possible site of antibody 



formation, 77 

 Thyroglobulin, antibody against, 5 1 

 Thyroxine, 50 

 Tobacco mosaic virus, 101 

 acylation of, 199 



complex formation with papain, pep- 

 sin, d-ribonuclease, tryp- 

 sin, 183, 185 

 infectivity, relation of phenol and 

 indole groups to, 199, 

 201 

 iodination of, 201 

 ketene, reaction with, 199 

 mutant strains, 101 

 phenylisocyanate, reaction with, 199 

 thiol groups, relation to viral activ- 

 ity, 201 

 Toxemia, gas-gangrene (CI. welchiO, 



357-361 

 ToxinCs) 



adsorption, on charcoal or red blood 



cells, 187, 188 

 antitoxin reaction, 159-160 



combinations, molecular ratios, 

 209-211 



SUBJECT INDEX 545 



bacterial, 335-342 



Clostridhim botulinum, crystal- 

 line, 187, 335-336 

 agglutination of red cells by, 

 336 

 neutralization by antitoxin, 

 336 

 pharmacological action of, 336 

 resistance to proteinases, 182 

 Clostridium oedematiens, 338 

 Clostridium tetani, 30, 31, 187; 

 crystalline, 336-337 

 avidity for tissue cells, 62 

 pharmacological action, 337 

 Clostridium welchii, 339-352 

 enzymatic activities of, 352- 



361 

 gas-gangrene caused by, 357- 



361 

 immunity against, 352-361 

 detoxification by tannic acid, col- 

 loidal particles, 186 

 diphtheriae, 30, 187 

 enzymes, comparison with, 187 

 formaldehyde, action of, 197 

 staphylococcal, 70, 103-104 

 elaboration in vivo, 296, 298 

 Toxoid, 187 

 Transamination, 375-377 



distribution in: Azotohacter vine- 

 landii, B. dysenteriae 

 (Shiga), B. -protens, B. yy- 

 ocyaneus, B. typhostis, E. 

 coli, Clostridium welchii, 

 Staphylococcus aureus 

 and alhus, Streptococcus, 

 hemolyticus and viridans, 

 376 

 pyridoxal phosphate, coenzjone of, 

 376 

 Tricarboxylic acid cycle, 371-373 

 Trypanosoma hritcei, 93 

 Trj^anosomes, persistence of, 93-94 

 indefinite latency, 93 



