CONTENTS XXI 



VI. The Occurrence of Lipids in the Animal as a Whole (continued) 



(b) The Effect on Subcutaneous Fat 580 



(c) The Effect on the Fat Content of Specific Tissues 582 



(d) The Effect of Ovariectomy on the Distribution of Storage Fat 584 



(e) Sex Differences in Fat Metabolism 585 



d. The Effect of Environmental Temperature 586 



(a) The Effect on Animal Fats 586 



(b) The Effect on Vegetable Fats 588 



e. The Effect of Exercise on the Distribution of Storage Fat 591 



f. The Effect of Diet on the Distribution of Storage Fat 591 



g. The Effect of Inanition on the Content and Composition of Body- 



Fat 593 



h. The Effect of Thyroxine on the Distribution of Storage Fat 596 



5. Variable and Constant Components of Lipids 597 



( 1 ) The Nature of the Constant Component 598 



(2) The Nature of the Variable Component 602 



6. The Lipid Distribution in the Cell 603 



7. The Physiology of Adipose Tissue 607 



( 1 ) The Specific Nature of Adipose Tissue 607* 



(2) The Specific Innervation and Blood Supply of Adipose Tissue 608 



(3) Changes in Fat Composition Occurring in Fat Depots 609 



a. The Mobile Nature of Fat in Fat Depots 610 



b. Fat Synthesis in Adipose Tissue 611 



c. The Control of Fat Mobilization and Deposition 612 



(a) The Metabolism of Adipose Tissue as a Controlling Factor. . 612 



(b) Hormone Control of Fat Mobilization and Deposition in Adi- 



pose Tissue 612 



a'. The Regulation by the Anterior Pituitary Gland 612 



b'. The Regulation by the Adrenal Cortex and Medulla 614 



c'. The Regulation by Insulin 615 



d'. The Regulation by Thyroid Hormones 616 



(c) Nervous Control of Fat Mobilization and Deposition in Adi- 



pose Tissue 616 



(4) Glycogen Deposition in Adipose Tissue 618 



(5) Normal Metabolism in Adipose Tissue 619 



(6) Enzyme Activity in Adipose Tissue 620 



(7) Brown vs. White Adipose Tissue 622 



8. Lipid Storage under Abnormal Conditions 623 



( 1 ) Abnormal Deposition of Triglyceride Fats in General 623 



a. Obesity Resulting from Overconsumption of Foodstuffs 624 



(a) Obesity Due to Hyperinsulinism 625 



(b) Obesity Due to Lesions of the Hypothalamus 625 



a'. Metabolic Aspects of Hypothalamic Obesity 628 



(c) Obesity Resulting from the Injection of Gold-Thioglucose. . . 630 



b. Obesity Resulting from Reduced Basal Metabolism 630 



c. Obesity Resulting from Reduced Activity 630 



d. Hereditary Obesity in Mice ._ 631 



