<£X11 CONTENTS 



VI. The Occurrence of Lipids in the Animal as a Whole (continued) 



(2) Abnormal Deposition of Triglycerides in the Liver 633 



a. Classification of Fatty Livers 633 



b. Description of Fatty Livers 635 



c. Conditions Related to the Development of Pathologic Fatty 



Livers 639 



(a) Choline and Choline Precursors as Lipotropic Agents 639 



a'. The Historical Development of Knowledge of the Lipotro- 

 pic Action of Choline 639 



b'. The Effect of Choline on Various Types of Fatty Livers . . 640 



c'. The Lipotropic Action of Proteins 642 



d'. The Lipotropic Action of Amino Acids 644 



e'. The Lipotropic Action of Proteins as Related to Their 



Amino Acid Content 647 



P. The Lipotropic Action of Compounds Related to Me- 

 thionine 649 



g'. The Biological Synthesis of Choline 650 



h'. Modification of the Lipotropic Action of Choline in the 



Presence of Methyl Acceptors 657 



i'. The Comparative Lipotropic Action of Choline Analogues 659 

 j '. The Physiological Role of Choline and Its Method of Ac- 

 tion 662 



k'. The Effect of Excessive Doses of Choline and of Methio- 

 nine 670 



(b) Fatty Livers Resulting from a Deficiency of Lipocaic 670 



a'. Experimental Evidence of Lipocaic in Tests on Dogs. . . . 670 

 b'. Experimental Evidence of Lipocaic Activity toward Fatty 



Livers Resulting from Choline Deficiency 671 



c'. Experimental Evidence of Lipocaic Activity toward Fatty 



Livers Resulting from Cholesterol 672 



d'. Lipocaic as a Hormone 672 



e'. Lipocaic as an Enzyme 673 



(c) Fatty Livers Resulting from an Inositol Deficiency 675 



(d) Fatty Livers Resulting from a Deficiency of Essential Acids. 678 



(e) Fatty Livers Resulting from an Excess of Cholesterol 679 



(f ) Fatty Livers Resulting from the Administration of Liver or of 



Liver Extracts (Biotin Fatty Livers) 681 



(g) Fatty Livers Resulting from Imbalances of the B Vitamins. . 681 



a'. Thiamine Fatty Livers 682 



1)'. Pyridoxine Fatty Livers 682 



c'. Pantothenic Acid Fatty Livers 682 



d'. Nicotinic Acid Fatty Livers 683 



(h) Fatty Livers Resulting from Hormones 684 



a'. Pancreatic Hormones 684 



b'. Hormones of the Anterior Pituitary Gland 684 



c\ Adrenal Hormones 685 



d'. Sex Hormones 686 



e'. Thvroid Hormones 686 



