84 II. DIGESTION AND ABSORPTION OF FATS 



Table 10 

 Teleost Fishes Having Cholic and Chexooksoxycholic Acids and Taurine in 



Their Bile 



Systematic name Common name Ref. 



Conger myriaster "Maanago," eel a 



Euthyrinus pelamin "Katsuwo," little tuna b 



Monacanthus cirrhifer "Kawahagi," file-fish, trigger-fish c 



Nibea mitsukurii, Jordan and "Nibe," corvina d 



Snyder 



Paralichthys olivaceus "Hirame," flat-fish, sole e 



Engraulis japonira, Tom- "Iwashi," anchovy f 



minck and Schlegel 



Sebastodes inermis "Meharu," rock-fish c 



Sebastodes matsubarae, Hil- "Ako," rock-fish g 



gendorf 



Siganus fuscescens, Houttuyn "Aigo" (Nagasaki), tang h 



Parasilurus asotus (Silurus "Namazu," sheat-fish, cat-fish, a 



pararulus) shad, wels 



Spams macrocephal us "Kurodae," sea-bream i 



Theragra chalcogramma "Suketo," North Pacific wall-eye e 



pollack 



a K. Takahashi and T. Mori, Arb. med. Fakulldt Okayama, 6, 358-360 (1940). 

 *> G. Sugivama, Arb. med. Fakultat Okayama. 6, 175-177 (1939). 

 e H. Ashikari, C. H. Kim, and T. S. Sihn, Arb. med. Fakultat Okayama, 6, 136-140 

 (1938). 



* T. S. Sihn and K. Maeda, Arb. med. Fakultat Okayama, 5, 542-544 (1938). 



* T. S. Sihn and C. H. Kim, Arb. med. Fakultat Okayama, 6, 49-53 (1938). 

 / N. Takeuti, Arb. med. Fakultat Okayama., 5, 319-322 (1937). 



' T. Ishihara, Arb. med. Fakultat Okayama, 5, 535-537 (1938). 



* T. Fukui, Arb. med. Fakultat Okayama, 5, 201-204 (1937). 



•' T. Hasagawa, Arb. med. Fakultat Okayama, 6, 84-86 (1938). 



During the 30-minute interval following the injection, an enormous amount 

 of bile salts was excreted, and most of the salts were free. In the succeed- 

 ing periods, a larger proportion of the bile salts was excreted in conju- 

 gated form, and less free cholate appeared. The experiments were later 

 confirmed on human subjects. 479 



Josephson 480 suggested an alternative hypothesis to explain his results. 

 The time required after the injection of free cholate before conjugated bile 

 acids appear in the bile may be the interval necessary for mobilizing or 

 producing the glycine or taurine needed for conjugation. The reaction is 

 similar to that involved in the formation of hippuric acid after benzoic 

 acid is administered; in fact, Josephson 480 considers it as not improbable 



479 B. Josephson and H. Larsson, Acta Med. Scand., 99, 140-146 (1939). 



480 B. Josephson, Physiol. Revs., 21, 463-486 (1941). 



