704 



VI. OCCURRENCE OF LIPIDS IN THE ANIMAL 



aZ., 961 - 962 Klenk et a 7 .., 946 - 963 and others 964 ~ 967 demonstrated that the cerebro- 

 side isolated from spleen contained glucose instead of galactose. However, 

 galactose may sometimes occur also. 967 In the case of Gaucher's disease 

 reported by Lieb, 950 galactose was found to be the component sugar in the 

 cerebroside. Brown and Morris, 968 in 1890, suggested that cerebrose is 



Ceramide (Li|noc_eric j^phingosine) 



C„H«C0MH 

 I CH,(CH,) tt CH-CH.CH.CH.CH, | 



Cerebroside 



C„H„C0NH 

 I CH,(CHi)bCH'CH.CH.CH.CH i i 



OH j 



I |___J 



CH,0H-CH-(CH0H),-CH 



Choline-phosphonc Acid 



Sphingomyelin 



C»H„C0NH 

 CH f (CH,) lt CH-CH.CH.CH.CH, 



Galactose 



or 

 Glucose 



Choline- 



phosphoric 



acid 



OH 

 ._+ 1 



0-P-OH 

 I 

 OCH 



,CH, /CH, 

 ^Nf CH, 



IV 



I X CH, 

 OH 



Fig. 5. A possible explanation for the synthesis of cerebrosides or sphingo- 

 myelin in the tissues from the intermediate, lignocerylsphingosine. 917 * 922 



identical with galactose. In view of the fact that both types of cerebroside 

 occur in normal spleen, 969 it is not permissible to consider the glucose-con- 

 taining cerebroside as abnormal. However, the fact that the newly formed 

 cerebroside in the tissues other than the brain in Gaucher's disease is usually 

 the glucose type, while that in the brain is the galactose variety, speaks 

 against the transportation and deposition theory in this disease. 



961 N. Halliday, H. J. Deuel, Jr., L.J. Tragerman, and W.E. Ward, J. Biol. Chem., 132, 

 171-180 (1940). 



962 N. Halliday, Proc. Soc. Exptl. Biol. Med., 75, 659 (1950). 



963 E. Klenk and F. Rennkamp, Z. physiol. Chem., 272, 280-282 (1942). 



964 I. S. Danielson, C. H. Hall, and M. R. Everett, Proc. Soc. Exptl. Biol. Med., 49, 

 569-571 (1942). 



965 Aghion, La maladie de Gaucher dans I'enfance, These, Paris, 1934; cited by E. Klenk 

 and F. Rennkamp, Z. physiol. Chem., 278, 253-268 (1942). 



966 J. Polonovski, Compt. rend., 215, 443-445 (1942). 



967 B. Ottenstein, G. Schmidt, and S. J. Thannhauser, Blood, 8, 1250-1258 (1948). 



968 H. T. Brown and G. H. Morris, /. Chem. Soc, 57, 57-59 (1890). 



969 E. Klenk and F. Rennkamp, Z. physiol. Chem., 273, 253-268 (1942). 



