FACTORS ALTERING CONCENTRATION OF BLOOD LIPIDS 417 



serum lipids in epileptic children receiving ketogenic diets composed al- 

 most exclusively of protein and fat. Tolstoi 369 likewise reported that a 

 hyperlipemia and a hypercholesterolemia occurred in two human subjects 

 who lived on an exclusive meat and fat diet for over a year. As soon as 

 the diet was discontinued, the levels of these components returned to 

 normal. In experiments designed for the study of the effect of dietary fat 

 on the iodine value of the blood fatty acids, Nhavi and Patwardhan 370 also 

 demonstrated that a correlation exists between the fat intake and the level 

 of lipid components in fasting blood. The results of these tests are sum- 

 marized in Table 13. 



Table 13 

 Average Values of Serum Lipids as Related to Fat Intake 



° Adapted from N. G. Nhavi and V. N. Patwardhan, Indian J. Med. Research, 34, 

 257-262 (1946). 



b Including standard deviation. 



b. The Effect of the Ingestion of Phospholipid on the Level of the Blood 

 Lipids. Although there is no doubt that phospholipids can originate from 

 fats in the intestinal wall and liver, there is some evidence that the blood 

 picture can be considerably modified when they are included in the diet. 

 Thus, in the tests of Flock, Corwin, and Bollman, 367 although the compo- 

 sition of the blood lipids in the dogs was not altered when fat was admin- 

 istered, either alone or with sodium choleate, a marked lipemia developed 

 within a week after the daily addition of 1 g. of crude lecithin from adrenal 

 glands to the regimen. This lipemia continued for the six-week period 

 during which the supplementation was continued. When the administra- 

 tion of phospholipid was discontinued, the blood lipids promptly returned 

 to normal. Neutral fat was the first blood constituent to be affected. 



369 E. Tolstoi, J. Biol. Chem., 83, 753-758 (1929). 



370 N. G. Nhavi and V. N. Patwardhan, Indian J. Med. Research. 84, 257-262 (1946). 



