FACTORS ALTERING CONCENTRATION OF BLOOD LIPIDS 443 



removal of this gland suppresses the ketosis and the fat infiltration into the 

 liver produced by the injection of the anterior pituitary extracts, 626 - 627 

 although demedullation of the adrenals did not prevent the accumulation 

 of liver fat in response to the anterior pituitary extract. 626 Moreover, 

 adrenalectomy was shown to decrease starvation ketosis, 668 as well as to 

 abolish sex differences in ketonuria. 659 On the other hand, the injection 

 of cortical extracts does not result in the production of ketonuria. 660 For 

 a further discussion of the subject of ketosis, see Volume III. 



Epinephrine (or adrenalin) , the chief hormone present in the adrenal me- 

 dulla, is now believed to be without an appreciable effect on the level of serum 

 lipids. 561-663 Himwich and Spiers 664 observed an increase in serum lipids 

 after the injection of moderate doses of epinephrine into dogs; similar re- 

 sults were reported in cats following emotional excitement and fright, due 

 to exposure to barking dogs, 565 to nocuous stimulation of the adrenals by 

 the application of electric stimuli to the pads of the feet, 566 as well as after 

 the faradic stimulation of the proximal end of the sciatic nerve. 567 However, 

 Long and Venning 563 believe that these results are erroneous; they ascribe 

 the positive findings of the above investigators to errors in the analytical 

 technic. Page, Pasternak, and Burt 568 reported that the injection of epi- 

 nephrine was followed by a decrease in the level of phospholipid, cholesterol, 



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 25, 188-193 (1931). 



849 C. A. Wright, Med. Record, 141, 191-196 (1935). 



550 D. Adlersberg, L. E. Schaefer, and S. R. Drachman, /. Clin. Endocrinol., 11, 67-83 

 (1951). 



561 J. W. Conn, W. C. Vogel, L. H. Louis, and S. S. Fajans, J. Lab. Clin. Med., 35, 

 504-517 (1950). 



852 C. J. Migeon, Proc. Soc. Exptl. Biol. Med., 80, 571-574 (1952). 



«» C. A. Winter, R. H. Silber, and H. C. Stoerk, Endocrinology, 47, 60-72 (1950). 



564 S. D. Kobernick and R. H. More, Proc. Soc. Exptl. Biol. Med., 74, 602-605 (1950). 



655 A. R. Rich, T. H. Cochran, and D. C. McGoon, Bull. Johns Hopkins Hosp., 88, 

 101-109 (1951). 



556 G. Sala, A. Amira, M. Borasi, and C. Cavallero, Lancet, 1951, I, 641-642. 



557 L. Levin and R. K. Farber, Proc. Soc. Exptl. Biol. Med., 74, 758-763 (1950). 

 668 E. M. MacKav and R. H. Barnes, Am. J. Physiol, 118, 184-189 (1937). 



689 E. M. MacKay and R. H. Barnes, Endocrinology, 22, 351-353 (1938). 



860 R. A. Shipley and E. G. Fry, Am. J. Physiol, 135, 460-463 (1942). 



861 M. Bruger and H. O. Mosenthal, J. Clin. Invest., 13, 399-409 (1934). 



862 E. F. Gildea and E. B. Man, J. Clin. Invest., 15, 295-300 (1936). 



863 C. N. H. Long and E. M. Venning, /. Biol. Chem., 96, 397-404 (1932). 



864 H. E. Himwich and M. A. Spiers, Am. J. Physiol, 97, 648-653 (1931). 

 868 H. E. Himwich and J. F. Fulton, Am. J. Physiol, 97, 533-534 (1931). 



866 J. F. Fazikas, M. A. Spiers, and H. E. Himwich, Proc. Soc. Exptl Biol. Med., 29, 

 236(1931-1932). 



867 Y. D. Koskoff and J. G. Dusser de Barenne, Science, 74, 550 (1931). 



868 1. H. Page, L. Pasternak, and M. L. Burt, Biochem. Z., 232, 295-309 (1931). 



