470 V. BLOOD LIPIDS 



able to produce typical vascular lesions by the use of cholesterol in the 

 diet, the reactions were less generalized. The effect of cholesterol feeding 

 on the production of atherosclerosis is discussed in the monograph of 

 Cowdry, 748 as well as in a number of more recent reviews. 749 " -755 



Some investigators, for example Gould, 756 believe that an equilibrium 

 exists between plasma cholesterol and liver cholesterol. This is not in- 

 variably the case, however, as is shown by the results of Marx et a?. 747 ; 

 these workers were unable to demonstrate any constant relationship, in 

 several species of animals, between the level of liver and of plasma choles- 

 terol and their relative susceptibility to atherosclerosis. These data are 

 summarized in Table 16. 



Table 16 



Cholesterol Content op the Blood Plasma and Livers of Several Species 



of Animals before and after Administration of a Diet Containing Cholesterol" 



a W. Marx, L. Marx, and H. J. Deuel, Jr., Am. Heart J., 4®, 124-128 (1951). 



The data summarized in Table 16 leave no doubt that the feeding of 

 cholesterol along with bile salts markedly increases the level of this sterol 

 in the plasma over that obtained on the cholesterol-free basal diet. In the 



748 E. V. Cowdry, Arteriosclerosis, MacMillan, New York, 1933, pp. 281-294. 



749 L. N. Katz, Circulation, 5, 101-114 (1952). 



750 A. Keys, Circulation, 5, 115-1 18 ( 1952). - 



781 J. W. Gofman, H. B. Jones, T. P. Lyon, F. T. Lindgren, B. Strisower, D. Colman, 

 and V. Herring, Circulation, 5, 119-134 (1952). 

 762 1. H. Page, Biol. Symposia, 11, 43-73 (1945). 



783 L. N. Katz and D. V. Dauber, J. Mt. Sinai Hosp., 12, 382-410 (1945-1946). 



784 R. Gubner and H. E. Ungerleider, Am. J. Med., 6, 60-83 (1949). 



788 W. B. Kountz, A. Sonnenberg, L. Hofstatter and G. Wolff, Biol. Symposia, 11, 

 79-86 (1945). 



786 R. G. Gould, D. J. Campbell, F. B. Kelly, Jr., C. B. Taylor, J. A. Hagerman, and 

 I. Warner, Circulation, 4, 479 (1951). 



