FACTORS ALTERING CONCENTRATION OF BLOOD LIPIDS 



471 



case of the hamster, the mean value of plasma cholesterol, when cholesterol 

 is administered with bile salts, is practically double that observed when 

 cholesterol is given alone. The highest levels of plasma cholesterol were 

 found in chickens and rabbits, which are two of the species susceptible to 



MOLECULES OF S, K5-30 CLASS 



| 1 MOLECULES OF S f 5-8 CLASS 



RABBIT REFERENCE NUMBER 



Fig. 5. Plot showing the relationship of the severity of atherosclerosis (as determined 

 by autopsy) to the concentration of S f 5-8 and S f 10-30 classes of molecules in the serum 

 of rabbits which had received cholesterol for 15 weeks prior to examination. 96 See p. 472. 



atherosclerosis. On the other hand, the picture is reversed when one com- 

 pares the figures for liver cholesterol in the species which are resistant to 

 atherosclerosis and in those which are susceptible to the condition, respec- 

 tively. The highest averages were reported in the livers of the hamsters 

 and rats; these animals are not subject to atheromas. Possibly the fact 

 that hamsters and rats have the ability to store the cholesterol more effi- 



