478 V. BLOOD LIPIDS 



lipoprotein concentration. The following chart prepared by Gofman 768 

 lists the defects in progressive order. 



"Normal" Pattern 



(1) Lipoproteins of Sf 4 and/or Sf 6 present at low or moderate concentrations. 

 Minimal levels of higher Sf components except for transient elevations in Sf 

 30-40,000 following fatty meals. 



"Minimal" Defect 



(2) Lipoproteins of Sf 4 and/or S f 6 at increased concentrations but without any 

 increase in higher Sf components as compared with (1). 



"Minor" Defect 



(3) Lipoproteins of S f 4 and/or Sf 6 plus Sf 8 in increasing concentration. 

 Progressively "More Severe" Defect 



(4) S/ 4 + S/ 6 + Sf 8 + Sj 10 



(5) Sf 4 + S f 6 + Sf 8 + Sf 10 + Sj 13 



(6) Sf 4 + Sf 6 + Sr 8 + Sf 10 + Sf 13 + Sf 17 



(7) S f 4 + Sf 6 + Sf 8 + Sf 10 + Sf 13 + 5/ 17 + St 17-20 



(8) Sf 4 + Sf 6 + S f 8 + Sf 10 + Sf 13 + Sf 17 + Sf 17-20 + Sf 20-40 



(9) Sf 4 + 5/ 6 + Sf 8 + 5/ 10 + S/ 13 + S/ 17 + Sf 17-20 + 5/ 20-40 + Sf 40-40,000 



(In this group the Sf 40-40,000 can be transient in existence, following meals, 

 or may be sustained even postabsorptively.) 



(10) "Most Severe" Defect 



As in (9) except that the Sf 4 and Sf 6 may be depressed to quite low concen- 

 trations. (This may be regarded as a general shift toward higher Sf lipopro- 

 teins, and is comparable to that which appears in the rabbits in the later phases 

 of cholesterol- Wesson oil feeding. ) 



Lipoprotein transport as a measure of lipid metabolic defect in man. 768 



e'. The Relationship of Total Serum Cholesterol to the Concentration 

 of the S f 10-20 Fraction: Gofman and co-workers 96 stated that analytically 

 determined values for blood cholesterol were highly unsatisfactory in re- 

 flecting the occurrence or progress of atherosclerosis. No correlation was 

 found between the occurrence of the "giant" cholesterol molecules and 

 the serum cholesterol values. Although there was a general trend toward 

 higher concentrations of the S f 10-20 molecules when the plasma cholesterol 

 exceeded 200 milligram per cent, sera having 120 to 140 milligram per cent 

 showed appreciable concentrations of the large cholesterol molecules in 

 some cases. However, after a thorough statistical evaluation of G of man's 

 data, Keys 769 concluded: "At the present time, it is entirely unjustified 



789 A. Keys, Bull. Johns Hopkins Hosp., 88, 473^83 (1951). 



