FACTORS ALTERING CONCENTRATION OF BLOOD LIPIDS 



479 



to attribute to G measurements any special virtues beyond that for simple 

 cholesterol measurements for the prediction of atherosclerosis or the estima- 

 tion of the activity of the atherosclerotic process." On the other hand, 

 Koehler and Hill 770 posed the question as to whether or not cholesterol 

 forms definite lipoprotein compounds. These workers proposed that 

 cholesterol becomes adsorbed on the protein molecules without forming a 



200 

 TOTAL 



250 

 SERUM 



300 350 400 



CHOLESTEROL, **$% 



Fig. 9. The average S f 12-20 lipoproteins of patients with coronary dis- 

 ease, and of normal persons of the 41- to 50-year age group plotted against 

 the total serum cholesterol. 768 



definite compound. On the basis of electrophoretic mobility studies, these 

 workers 771 postulate that no large serum lipoprotein complexes exist in 

 arteriosclerosis. 



In more recent studies, Jones, Gofman et al. 767 reported marked differ- 

 ences between the S f 12-20 lipoproteins in the sera of blood of normal pa- 

 tients forty-one to fifty years of age, as contrasted with patients with cor- 

 onary disease, of the same age group. These results are plotted in Figure 9. 



770 A. E. Koehler and E. Hill, Federation Proc, 11, 241 (1952). 



771 A. E. Koehler and E. Hill, Federation Proc, 12, 232 (1953). 



