BEHAVIOR OF BACTERIOPHAGE IN DISEASE 



443 



active for the Shiga organism (-f), extremely active for B. coli 

 (+ + + +), and but very shghtly active for the dysentery bacillus 

 found in the patient (+). Against this last bacillus the virulence in- 

 creased during the course of the three following days, reached its maxi- 



Chart 4. Jean Ker (6 years) Dysentery (Shiga) 



[ B. dysenteriae from the patient- 



\b. 



Virulence for -j B. dysenteriae, stock strain 



[ B. coli 



Stools contained blood^= 



mum activity (+ + + +), fell away somewhat (+ +), and then 

 definitely regained its full virulence (+ + + +). These fluctuations 

 in virulence were reflected in the condition of the patient. At the end 

 of convalescence there remained only a slight activity (+) of the bac- 

 teriophage and that was directed against B. coli. 



