BEHAVIOR OF BACTERIOPHAGE IN DISEASE 459 



1. Renee Mar (thirty-two years, chart 9). 



The bacteriophage was from the beginning virulent for B. coli and 

 remained so during the course of the disease, throughout convalescence 

 and up to the time when the patient was discharged from the hospital 

 completely cured. It may be noted that the acquisition of virulence 

 by the bacteriophage for the bacillus of the infection coincided with the 

 first defervescence. Then this virulence became reduced and the tem- 

 perature again went up. The infection was definitely overcome at the 

 time when this virulence was again estabHshed. 



2. Juliette Ou (thirty-six years, chart 10). 



3. Jeanne Del (twenty years, chart 11). 



The curves for these cases are self-explanatory. 



3. Typhoid fever with relapse 



1. Gilberte Fon (four years, chart 12). 



On the sixteenth day the disease appeared ended. However, the 

 virulence of the bacteriophage toward the bacillus of the patient dis- 

 appeared before the end of the crisis and the destruction of the path- 

 ogenic bacteria was not complete. Whereupon there was a relapse, 

 very severe, which did not show improvement until the bacteriophage 

 recuperated with a virulence sufficient to control the resistance of the 

 bacterium. 



4. Typhoid fever of extreme severity 



1. Andree Dess (thirty years, chart 13). 



2. Jeanne Cot (twenty-four years, chart 14). 



In these two cases strains of B. typhosus were isolated at different 

 times during the course of the disease. These bacilli presented a marked 

 resistance to the action of a very active strain of Typhoid-bacteriophage 

 and lost this resistance only after about ten transfers on agar. It is 

 to be noted that at their isolation from the body these baciUi were inag- 

 glutinable (this fact has frequently been observed) and that they did not 

 become agglutinable until after a series of subcultures. This transitory 

 inagglutinability is, as we have seen, associated with resistance to the 

 action of the bacteriophage. 



Examination of the curves shows clearly the struggle which was car- 

 ried on within the organism between the bacterium and the bacterio- 

 phage and the repercussions of this campaign upon the state of the 

 patient. 



