SPECIFIC THERAPY WITH BACTERIOPHAGE SUSPENSIONS 555 



Recovery, clinically and bacteriologically, was complete 4 days after 

 the first injection. 



Along with the many cases where recovery was obtained in a manner 

 as abrupt as in the cases cited above, Hauduroy encountered some ab- 

 solute failures.* 



Phihbert and his associates (^"), at the Hopitaux de Paris, have 

 treated many cases of B. coli urinary infections. Here are their 

 conclusions: 



Colon bacillus infections, particularly septicemia and pyelonephritis, are 

 improved or cured with great facility by the anti-coli bacteriophage. Recovery, 

 occurring in all of the cases which we have observed within 24 to 48 hours, is 

 evidenced by a clearing of the urine, a cessation of the pains, a disappearance 

 of the pollakiuria, a regression of the renal swelling, a fall in the temperature, and 

 in a general improvement. The fall in temperature may take place either ab- 

 ruptly, or by lysis, and is accompanied by a diaphoretic crisis. 



After remarking that in certain cases, recovery does not take place, 

 a result which, they say, is primarily due to the fact that the bacillus 

 of the patient is not susceptible to the bacteriophage used, they add: 



Every case of colibacilluria is subject to this treatment, whether it is a case of 

 pyelonephritis of pregnancy, of calculus, of intestinal or of septicemic origin. 

 We often encountered coli bacillurias associated with, or secondary to, intestinal 

 disturbances in tabetics, in patients who were constipated or had an enteritis, 

 and it seemed as though the intestinal disturbance as well was improved by the 

 bacteriophage treatment. 



Arloing, Dufour, Bouvier and Sempe-" have also obtained extremely 

 rapid cures in cases of pyelonephritis,! and Munter and Boenheim'*" 

 report the successful treatment of pyelitis in infants, while Pereira^°° 

 has treated urinary infections in adults. 



* The method employed by Hauduroy for the preparation of the suspensions of 

 Coli-bacteriophage was as follows : After having isolated a large number of races 

 of the bacteriophage virulent for B. coli he maintained by successive passages 

 two races which were distinctive because of their wide range of virulences. The 

 B. coli under test is planted in bouillon. When the turbidity is slight, but quite 

 evident, a mixture of these two races of the bacteriophage is added, and bacte- 

 riophagy is allowed to take place at 22°C. When the material becomes clear a 

 concentrated suspension of the B. coli strain is added and bacteriophagy takes 

 place a second time at 22°C. The medium again being clear, it is filtered through 

 a candle and distributed in ampoules which are kept in the ice-box until used. 



t Marcuse^^^ has succeeded in producing an experimental colon bacillus cystitis 

 in guinea pigs. They were cured by the bacteriophage. 



