SPECIFIC THERAPY WITH BACTERIOPHAGE SUSPENSIONS 567 



the following days improvement continued. At the time when I saw 

 the patient the general condition was perfect, and the healing of the 

 wound was far advanced. 



Treatment by the bacteriophage is so simple and the action is so rapid, 

 that it should be applied routinely in all cases of suppurating wounds. 



7. BACTERIOPHAGE THERAPY OF STREPTOCOCCUS INFECTIONS 



In connection with his work on staphyloccoccus infections McKinley^^" 

 has reported one case of a streptococcus infection treated with the 

 bacteriophage. 



F. N., aged 39. The patient was first seen on March 9, the present 

 illness being of 3 weeks duration. The essential points in the examina- 

 tion were; many streptococci in smears of the fluid from the chest, and 

 the presence of an abscess of the lower part of the right lung, as revealed 

 by Roentgen-ray examination. 



March 13: A rib resected and drainage instituted. 



March 14: There was considerable drainage with a foul odor. 



March 15: The condition was the same. 



March 17: The condition was the same. Thirty cubic centimeters of a strep- 

 tococcus bacteriophage were injected into the cavity. 



March 18: There was a large amount of drainage. The odor was not so bad. 



March 19 : There was a small amount of drainage and hardly any odor. 



March 20: Thirty cubic centimeters of bacteriophage were injected into the 

 cavity. There was little discharge and no odor. 



March 21: The condition remained the same. 



March 22 : There was practically no discharge and no odor. 



March 23: There was no discharge. Twenty-five cubic centimeters of bac- 

 teriophage were injected into the cavity. 



March 25: The patient was discharged from the hospital. He said that he 

 "felt fine." 



May 15: The patient returned and said that he had felt perfectly well since 

 leaving the hospital. 



Needless to say, the conditions under which the bacteriophage may 

 be used in streptococcus infections, and the limitations as regards re- 

 peated administration, are the same as in the case of staphylococcus 

 infections. 



8. BACTERIOPHAGE THERAPY IN BUBONIC PLAGUE 



In 1920, while in Indo-China, I isolated several races of the bacterio- 

 phage virulent for B. pestis. One race, in particular, derived from a 



