SPECIFIC THERAPY WITH BACTERIOPHAGE SUSPENSIONS 



573 



reaction, for 16 hours after the injection, in all cases, the bubo was less 

 painful. 



On the morning of the 18th, as with the preceding cases, 60 hours 

 after the inoculation, I withdrew some of the material from the gland. 

 Direct examination, culture, and guinea pig inoculation, all showed that 

 the contents of the bubo were sterile. A suspension of plague bacilli, 

 added to the bouillon which had shown no growth, failed to develop 

 and were completely bacteriophaged in 7 hours. 



The bubo absorbed slowly. On the 8th of August it was still as large 

 as a pea. 



Chart 24. Theodoro Cass Bubonic Plague 



Treatment consisted in a single injection of Pestis-bacteriophage 



The temperature curve is given (chart 24). 



Case 4. A. Stell 32 years old. Steward. 



During the morning of July 25, while still at sea, the patient was taken 

 with fever, chills, headache, and had a swelling in the region of the groin. 

 On the forenoon of July 27th the ship arrived at Alexandria, and at the 

 time of the Quarantine Service inspection the patient had a temperature 

 of 40°C., the eyes were injected, and the tongue was dry and brownish. 

 The prostration was marked. The patient could speak only with 

 difficulty. The pulse was 120 and irregular. In the right groin there 

 was a bubo about the size of a nut and very painful. 



At 4 o'clock in the afternoon I removed some of the contents of the 

 gland, and bacteriological examination later confirmed the diagnosis of 

 bubonic plague. Immediately after the removal of the material from 



