202 GOTTWALT CHRISTIAN HTRSCH 



Trial and error 



The communication between the endoplasmic reticulum and the 

 zymogen granules and the way by which the enzymes are absorbed by the 

 Golgi lamellae is not entirely clear. Recently I found in the micrographs 

 of Palade between the endoplasmic reticulum and the Golgi lamellae many 

 round shaped X-bodies of about 370 A diameter. (Fig. i.) The internal 

 shape of these bodies is varying. It is only theoretical to say this : 



1. On the end of the ER in the Golgi field, ruptures of the ER mem- 

 branes are to be seen in the direction to the Golgi field. Through these 

 ruptures the protein content of the ER seems to go out to the space between 

 ER and Golgi lamellae. 



2. These proteins may form the X-bodies ( }) It is, however, only the 

 topographical relationship that gives this idea. 



3. These X-bodies may be taken up by the Golgi vacuoles and packed 

 up to large zymogen granules. This process, however, is far from being 

 clear. 



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