CONTENTS 17 



T'A(iK 

 Union of Egg and tSperm; 8pecilicity and Genetics; Production 

 of Specific Hormones, 318; Immunological Specificity; Durham's 

 Explanation — Multiple Antigens, 319; Precipitins and Specificity; 

 Precipitins and Species Kelationsliip ; Serological Types Within a 

 Species; Bacterial Types Within a Species, 320; Serum Proteins 

 vs. Cellular Antigens; Properties of an Antigen; Animal Proteins, 

 321; Red Cell Proteins; Tissue Proteins; Organ Specificity; Lens 

 and Testicular Proteins Show Nonspecies Specificity, 322 ; Keratin, 

 Mucin, etc.. Lack Species Specificity; Thyroglobulin ; Milk Pro- 

 teins; Antigenic Components of the Egg, 323; Biological and Im- 

 munological Relationships Among Ameba; Vegetable Proteins; 

 Algae, 324; Antigens in Fungi; Bacterial Antigens; Structure and 

 Properties of Proteins, 325; Importance of Physical and Chemical 

 Changes in Antigen, 326; Enzyme Action Destroys Antigenic Prop- 

 erty; Relationship of Digestibility and Antigenic Property; Pos- 

 sible Number of Compounds Formed by Amino Acids, 327; Impor- 

 tance of Aromatic Amino Acids in Protein Antigens; Acid and 

 Basic Groups of Amino Acids; Aliphatic and Aromatic Amino 

 Acids, 328; Zozaya's Nonprotein Antigen, 329. 



CHAPTER XVIII 



Modified and Conjugated Antigens ___________ 332 



Early Work on Modified Antigens; Early Work on Conjugated 

 Antigens, 332; Altered or Modified Antigens; Iodized Protein; 

 lodotryptophane, 333; Acetylated Proteins, 334; Conjugated Anti- 

 gens of Landsteiner-Diazo Compounds; Coupling With a Protein; 

 Arsonic Haptens, 335; Arsonic Protein Compounds; Aliphatic 

 Side Chains Not Diazotizable, 336; Protein Structure, 337; Ni- 

 troso Compounds; Azo Dyes; Cysteine and Cystine, 338; Stereo- 

 isomers or Spatial Relationships, 339; Position Isomers, 340; 

 Linkage With Salt-Forming Groups; Removal of Acid Properties 

 of an Amino Acid, 341; Removal of Basic Properties of an Amino 

 Acid; Other Ways of Salt Formation, 342; Effect of Esterification 

 and Methylation of Protein; Cross Reactions; Specific Reactions, . 

 343 ; Formalized Rabbit Serum as an Antigen ; Recent Work on 

 Iodized Antigens, 344; Minimum Amount of Iodine to Change 

 Antigenic Property; Specificity for Iodized Proteins; Group Reac- 

 tions Due to Different Haptens in the Same Molecule, 345; Egg 

 Albumen Contains Tyrosine and Histidine. Gelatin Contains Histi- 

 dine; Use of Diazo Dyes for Suppression of Specific Reaction; 

 Tyrosinediazoarsanilic Groups in Protein Molecule, 346; Tyrosine- 

 Like Diazoarsanilic Acid Dye; Histidindiazoarsanilic Acid Groups 

 in Gelatin Molecule; Histidine-Like Diazoarsanilic Acid Dye, 347; 

 Antibodies to Strychnine, 348. 



