CONTENTS 19 



PAGE 

 Titer Following Vaccinatiou, 'dSi; Effect of Allergy on Agglutinin 

 Titer; Experimental Eesults on Agglutinin Variation; Time of Ap- 

 pearance of Maximum Titer, 385; The Use of the Widal in Vac- 

 cinated Individuals ; Importance of ' ' Fine Granular ' ' and ' ! Loose 

 Flocculation " ; Time and Temperature of Incubation, 386; Undu- 

 lant Fever, 387; Tularemia; Agglutinin Eesponse to Infection in 

 Partially Immune Animals, 388; The Effect of Specific Infection 

 on the Titer of Agglutinin for Other Organisms; Felix-Weil Phe- 

 nomenon, 389; Tularemia — Specific and Cross Reactions With Br. 

 Abortus Antigens, 390 ; Antigenic Eelationships Between S. Galli- 

 narum and E. Typhosa, 391; The Agglutination Reaction in Other 

 Specific Infectious and Toxemic Diseases — S. Dysenteriae ; Gland- 

 ers; Asiatic Cholera and a Few Other Diseases; Test for Heter- 

 ophile Antibodies in Acute Infectious Mononucleosis; Identification 

 by Agglutination or Precipitation, 392; Bacterial Types; C. Diph- 

 theriae, 393; CI. Tetani; CI. Botulinum; E. Typhosa; Pneumo- 

 coccus Typing, 394; Technique Neuf eld's Quellung Reaction; 

 Sabin's Description of Neufeld's Method, 395; Typing of Hemo- 

 Ij'tic Streptococci, .'{9(5; Skin Tests for Antibodies; Tlie Francis 

 Skin Test, 397. 



CHAPTER XXII 



The Basis of Bactkiual Compj.ement Fixation Technique _ _ _ _ 401 

 Introduction; The Original Bordet-Gengou Technique, 401; Appli- 

 cation of Complement Fixation, 402; Reagents and Factors In- 

 volved ; Development of Modern Technique, 403 ; No Hemolysis in 

 Tube 5, 409; Complete Hemolysis in Tube 5; Object of Controls; 

 Results WTien Fixation Is Due to Antibodies, 412; Quantitative and 

 Qualitative Tests; Reading the Results; Reporting Results; Corre- 

 lation With Clinical Findings; Discussion, 413; Variation in Titer 

 of Hemolysin; Variation in Agglutinin and Precipitin Titer, 414; 

 Antibody Variation During Infection; Summary of Recommenda- 

 tions, 415. 



CHAPTER XXIII 



Complement Fixation in Syphilis ___________ 419 



History of Syphilis; Etiology, Incubation and Primary Lesion; 

 Laboratory Procedure Indicated During Primary Stage, 419; Blood 

 Tests of Little Value During Primary Stage, 420; Secondary Stage 

 — Time of Appearance of Symptoms, Laboratory Findings and 

 Duration; Complement Fixation and Precipitin Tests in Untreated 

 Cases and Treated Cases ; Syphilis May Clinically Resemble Almost 

 Any Disease, 421; Syphilis Characterized by Periods of Latency 

 Followed by Periods of Activity; Serology of Umbilical Bloods; 

 Tertiary Sj-philis, 422; Tabes, Paresis, and Cerebrospinal Lues I^ate 



