CONTENTS 21 



CHAPTEK XXV page 



Hypersensitivkness ________________'±70 



Discovery of Anaphylaxis; Early Studies of Anaphylaxis, 470; 

 Eichet and Portier's Work; Arthus Phenomenon; The Theobald 

 Smith Phenomenon; Rosenau's and Anderson's Studies, 471; Dis- 

 covery of Passive Sensitization; Sensitizing Substance, 472; Sensi- 

 tizing Dose of Antigen; Incubation Period in Active Sensitization, 

 473; Duration of the Hypersensitive State; Shocking Dose of Anti- 

 gen, 474; Passive Sensitization, 475; Desensitization; The Refrac- 

 tory State, 476; Anaphylaxis in the Guinea Pig — Acute Shock, 477; 

 Protracted or Subacute Shock in the Guinea Pig; The Dale Phe- 

 nomenon, 478; Anaphylactic Shock in the Rabbit, 479; Protracted 

 Anaphylactic Shock in the Rabbit; Local Anaphylaxis or Arthus 

 Phenomenon; Anaphylaxis in the Dog, 480; Anaphylaxis in the 

 Cat, 481 ; Anaphylaxis in Eats, 482 ; Anaphylaxis in Frogs ; An- 

 aphylaxis in Turtles, 483; Anaphylaxis in Chickens; Anaphylaxis 

 in Monkeys, 484; Anaphylaxis in Man; Criteria of Anaphylaxis, 

 485; The Sensitizing Antibody, 486; Specificity of the Reaction; 

 The Changes in Metabolism During Shock, 487; The Nature of 

 Anaphylaxis, 488; Site of Reaction, 489; Tissues Involved in An- 

 aphylaxis, 490 ; Mechanisms of the Reaction, 492 ; Further Discus- 

 sion of the Pliysical Tlicory, 494 ; Further Discussion of the His- 

 tamine Theory, 495. 



CHAPTER XXVI 



Hypeksensitiveness Due to Infection __________ 504 



Allergy in Tuberculosis; Tuberculosis and Tuberculin Hyperseusi- 

 tiveness; Tuberculin OT, BE, and TR; Objections to OT ; Long's 

 Synthetic Medium, 504 ; Synthetic Medium of the Bureau of Animal 

 Industry; The Active Substance, Its Recovery and Properties, 505; 

 TPT of Seibert and Munday, 506; Seibert's SOT and SOTT or 

 PPD, 507; MA-100 of Funk and Huntoon; Relationship of 

 Lrolecular Weight to Sensitizing Property, 508; Chemical Nature 

 of PPD, 509; Classification of Standardization Methods; Koch's 

 Method; Method Used in the Institute of Experimental Therapy, 

 Frankfurt, 510; Method of U. S. Bureau of Animal Industry; 

 Skin Test Method of Lewis and Aronsor. ; Standardization of 

 Tuberculin by the Precipitation Method of Dreyer and Vollum, 

 511; Complement Fixation Method of Watson and Heath; Ob- 

 jections to Lethal Tests, 512; Advantages and Disadvantages of 

 the Various Tests, 513; Standardization by Long's Sper- 

 matocyte Reaction; Spermatocyte Tuberculin Unit, 514; Depend- 

 able Methods of Tuberculin Production and Standardization; Diag- 

 nostic Tuberculin Tests; The von Pirquet Test, 515; Moro 's Percu- 

 taneous Test; Wolff -Eisner Test; Patch Test; Mantoux Test, 516; 

 Funk and Huntoon 's Results With OT and MA-100; Dosage Em- 

 ployed; Reading the Reactions, 517; Incidence of Reactions in 



