140 IMMUNOLOGY 



the heart, to these glucosides. This is of interest in view of the 

 resistance of the rat to diphtheria toxin. This has been studied 

 extensively by Coca and others. The toxin apparently circulates 

 in the blood and does not combine with the tissues. Further work 

 is apparently necessary before such a phenomenon can be desig- 

 nated as a significant factor in active immunity in man. 



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