518 IMMUNOLOGY 



17 mm. for the erythema and 13.4 mm. for the edema produced by 

 OT as compared with 20.1 mm. for the erythema and 11.2 mm. for 

 the edema caused by the MA-100. They observed no necrosis in 

 any of the reactions with MA-100 although the induration per- 

 sisted for several weeks in a few individuals. Occasionally super- 

 ficial necrosis was observed in the reactions produced by OT. No 

 general symptoms were noted in any of the individuals tested. 



Incidence of Reactions in Known and Suspected Cases of 

 Tuberculosis. — In a series of 204 cases of pulmonary tuberculosis 

 94.1 per cent were positive to MA-100 while 90.6 per cent were posi- 

 tive to tuberculin OT. In 57 cases of suspected tuberculosis the 

 percentage of positive reactions was 92.9 with MA-100 and 91.2 

 with tuberculin OT. 



Incidence of Reactions in Clinically Nontuberculous Cases. 

 — It is interesting to note that in a scries of 137 adult patients, all 

 clinically ?ir>ntube7'culous, Funk and Iluntoon found 81 per cent 

 positive reactions to MA-100 and 71.5 per cent to tuberculin OT. 

 In another series of 25 cases also clinically nontuberculous the 

 percentages of positives were 80 and 68, respectively. They also 

 tested 43 children whose ages varied from one to twelve years 

 (average 5.3 years) and found 25.5 per cent positive to J\IA-100 

 and 16.2 per cent to tuberculin OT. 



Noncorrelative Reactions. — In the series of clinically tuber- 

 culous cases cited above there were 12 individuals who reacted 

 to tuberculin MA-100 and not to OT and 5 who reacted to the 

 latter but not the former. 



Cases of Tuberculosis That Did Not React. — There were also 

 13 clinically tuberculous individuals who did not react to either 

 MA-100 or OT. Eight of these patients were quite ill, three of 

 them were described as cachectic. The condition of the five re- 

 maining individuals was regarded as either fair or good. In this 

 connection Rich and McCordock (1929) as well as others call at- 

 tention to the fact that tuberculin tests may be negative in 3 to 5 

 per cent of the cases of miliary tuberculosis and may be sup- 

 pressed in certain of the exanthematous diseases as well as during 

 labor and the puerperium. 



Mariette and Fenger's Results With MA-100 and OT.— More 

 recently Funk, Huntoon and White have collaborated with Mari- 

 ette and Fenger (1932) in an extensive study of the skin reactions 



