SIGNIKICANCK OF AI.LERGV 000 



8. Shwartzman discovered that the culture filtrates of certain 

 kinds of bacteria, e.g., E. typhosa, EscJi. coli, the meningococci, 

 streptococci and a few other bacteria, contain what he designated 

 as a skin preparatory and reacting factor respectively. If a small 

 amount of such a filtrate is injected into the skin of a rabbit, 

 and twenty-four liours later an intravenous injection of the 

 same or any other filtrate that contains the reacting factor is 

 administered, there develops a severe hemorrhagic reaction at 

 the site of the primary skin injection. In Shwartzman 's opinion 

 the phenomenon is due to a local disturbance of cell function 

 produced by the filtrate. He reports that the skin preparatory 

 and reacting factors of a filtrate may be neutralized by the addi- 

 tion of its homologous immune serum. A few additional observa- 

 tions are reported. 



9. Allergy in lymphogranuloma inguinale is mentioned and a 

 skin test as originally described by Frei is described and discussed. 

 The etiological factor is apparently a filtrable virus which Tamura 

 reports having cultured in vitro. According to Tamura the super- 

 natant fluid of positive cultures can be heated and used success- 

 fully in skin testing or in immunization. If his results are con- 

 firmed, a commercial antigen should be available in the near future. 



References 



Ando, K., and Ozaki, K.: Studies on the "Toxins" of Hemolytic Strepto- 

 cocci. V. The Dick Test and Allergic Skin Reactions to Strepto- 

 coccus Nucleoproteins, J. Immunol. 18: 267, 1930. 



Apitz, K. : A Study of the Generalized Shwartzman Phenomenon, J. Im- 

 munol. 29; 2.55, 1935. Studies on the Chemical Nature of Shwartz- 

 man Active Substances, Ibid. 29: 343, 1935. 



Birkhaug, K. E.: Protection Against Tuberculosis with B. C. G. Vaccine in 

 Guinea Pigs. Am. Rev. Tuberc. 27: 6, 1933. 



Bohmig, R., and Swift, H. F. : Comparative Histologic Reactions in Cu- 

 taneous Lesions Induced by Streptococci in Rabbits Previously 

 Inoculated Intracutaneously or Intravenously, Arch. Path. 15: 

 611, 1933. 



Cannon, P. R., and Hartley, M. A., Jr.: The Failure of Allergic Inflamma- 

 tion to Protect Rabbits Against Infection with Virulent Pneumo- 

 cocci, Am. J. Path. 14: 87, 3938. 



Cannon, Paul R., and Sullivan, F. L.: Local Immunity and the Local 

 Formation of Antibodies, Am. J. Path. 8: 597, 1932 (Abstract), 



Clawson, B. J.: Experimental Vaccination with B. C. G., Am. J. Path. 10: 

 664, 1934 (Abstract), 



Clawson, B. J.: Studies on the Etiology of Acute Rheumatic Fever, J. 

 Infect. Dis. 36: 444, 1925. 



Clawson, B, J.: Experimental Subcutaneous Rheumatic Nodules, Am. J, 

 Path. 4: 565, 1928. 



