636 



SUBJECT INDEX 



Toxins — Cont 'd 



and antitoxins, 241-275, 276-305 



bacterial, discovery of, 32 



definition of, 33, 241 



effect of CI. welehii and others on 

 tissues, 297 



flocculation of purified, 250 



gaseous gangrene and, 295 



history of active immunitv studies 

 of, 258, 259 



incubation period of, 29 ti 



insusceptibility of mice and rats to, 

 243 



kinds of, 241 



optimal proportions of ricin and 

 antiricin, 230 

 proportions of venoms and anti- 

 venoms, 230 



pathology in lower animals due to, 

 243, 244 



phytotoxins, 34, 35 



similarity of, from streptococci of 

 erysipelas and scarlet fe- 

 ver, 278 



symptoms in susceptible animals 

 caused by, 243 



theory of incubation period, 243 



true, 241 



zootoxins, 34, 35 

 Toxoid, age and reactions to, 260, 263 



alum, 263 



dosage of, 265 



diphtheria, 117 



elimination of, 264 



history and method of preparation, 

 261 



history of, 247 



immunization with, by inunction, 

 263 



immunized with combined, 263 



number of injections necessary, 264 



plain, dosage. New York Depart- 

 ment of Health, 265 



preparation of, 247 



Eamon, 261 



specifications of U.S.P.H.S., 262 



tetanus, 116, 118 

 Toxone, definition of, 251 

 TPT, Seibert's, 507 

 Trachea, function of cilia, 133 



lymphatics of, 76 

 Transfusion, immuno-, 281, 283 



reference to transmission of syph- 

 ilis by, 439 

 Transpleural mobilization, protection 



and, 128 

 Trauma, definition of, 72 



Treatment, use of active-passive im- 

 munity in tetanus or diph- 

 theria, 264 

 Treponema pallidum, demonstration 

 of, 420 

 effect of malaria on infection 

 with, 31 

 Triple allelomorph theory, 178, 179, 

 188 

 vaccine (T.A.B.), use of, 115 

 Trypan blue, effect on anaphylaxis, 



490 

 Trypanocidal effect, zone phenomenon 



and, 252 

 Trypanosome lewesi, 30 

 antibodies and, 152 

 effect of immune serum on, 253 

 Trypsin, anaphylaxis and, 476 

 Tryptophane, iodizing of, 333 

 T : S ratio, in normal and immune an- 

 imals, 132 

 Tubercle bacillus, increase of viru- 

 lence of B.C.G., 549 

 tissue reactions to fractions of, 



524 

 varieties of, 59 

 formation of, 57 

 phosphatid stimulation and, 59 

 role of, in tuberculosis, 542 

 Tuberculin, active substance of, 505, 

 509 

 allergy, and anaphylaxis, possible 

 explanation of dissimilari- 

 ties, 526, 527 

 antigen-antibody mechanism the- 

 ory, 529, 530, 532 

 Birkhaug's views on, 541 

 comparison of, with immune re- 

 sponse, 528, 532 

 comparison witli anaphylaxis, 



526-532 

 Dienes' work on, 526, 527, 528 

 discussion of antigen-antibodv 



concepts of, 530-532 

 effect of histaminase on, 532 

 epithelium and antibodies, 531 

 general conclusions concerning, 



532, 533 

 intravenous vaccination and, 541 

 necessary factors for, 524-526 

 chemical nature of PPD, 509 

 diagnostic tests with, 515, 516 

 dosage of MA-100 employed, 517 



of Mariette and Fenger, 519 

 effect of age upon, 522 

 fractions of, 354 



importance of molecular weights 

 of, 508, 509 



