REGULATION 163 



will be transmitted to the clone. Heterogeneity among the population will 

 be achieved through the channel of this inducible antigen-capture system, 

 without change in the genetic material. 



Szilard (1960) also developed a theory which rests entirely on the 

 presently accepted views about induction and repression of enzyme 

 synthesis and on feedback mechanisms. It gives an interpretation of all the 

 major facts of antibody production, but this is at the cost of several 

 assumptions. 



All these theories of antibody formation are extremely attractive; they 

 are unfortunately highly speculative, because facts are scarcer than ideas in 

 the present state of biochemistry of antibody synthesis. Progress in cell 

 cultivation methods and the possibility of studying antibody production 

 in "vitro might pave the way for a new type of experimental approach. One 

 may hope that these brilliant working hypotheses will help to design clear 

 experiments and will thus eventually lead to a better understanding of this 

 intriguing process, which is not of academic interest only. A broad field 

 lays open for experimentation. 



