Contents 



INTERMEDIATE CARBOHYDRATE METABOLISM 

 By Otto Meyerhof, University of Pennsylvania . 



Introduction, 3 



Inadequacy of older views of the 

 relation between aerobic and an- 

 aerobic carbohydrate breakdown, 4 



Alternate pathways of oxidation, 4 



The oxidation quotient, 5 



Competition of oxygen and pyruvate 



in oxidation of dihydrocozymase, 6 



Aerobic phosphorylation, 7 



Reversibility of the glycolysis re- 

 actions, 9 



Formation of phosphopyruvate from 

 pyruvate through oxalacetate, 12 



Inhibitors, 14 



OXIDATIVE MECHANISMS IN ANIMAL TISSUES 

 By Eric G. Ball, Harvard Medical School .... 



Introduction, 16 



Oxygen activation and the cyto- 

 chrome system, 17 



Substrate activation and the pyri- 

 dine nucleotide and flavoprotein 

 systems, 18 



The energy relationships of these 

 systems and the transfer of elec- 

 trons between them, 21 



The relative concentrations of cyto- 

 chrome c, diphosphopyridine nu- 

 cleotide, and flavoprotein in animal 



16 



tissues and their possible signifi- 

 cance, 25 



The possibility of the existence of 

 pathways alternate to the cyto- 

 chrome system, 26 



Cyanide poisoning of respiration and 

 a theory of its mechanism, 27 



An interpretation of respiratory 

 mechanisms in tlie arbacia egg, 30 



Azide poisoning of respiration and 

 a possible interpretation of its ac- 

 tion on muscle respiration, 30 



DISCUSSION ON HYDROGEN TRANSPORT 

 Van R. Potter, chairman 



33 



The Possible Role of Intermedi- 

 ary Metabolites as Hydrogen 

 Carriers by K. A. C. Elliott, 33 



The Role of the Carriers in Dis- 



MUTATIONS AND CoUPLED OxiDO- 

 REDUCTIONS, WITH SPECIAL REFER- 

 ENCE TO THE Flavoproteins by 



E. G. Ball and F. Lipmann, 38 

 The Physico-Chemical Mechanism 

 OF Hydrogen Transport by Kurt 

 Stem and Erwin Haas, 42 

 Possibility of a By-Pass around 

 the Cytochrome System by El- 

 mer Stotz, 46 



PASTEUR EFFECT 



By Fritz Lipmann, Massachusetts General Hospital 



48 



The efficiency of aerobic and an- 

 aerobic metabolism, 50 



The metabolic structure of cells, 52 

 Bacteria, 53 

 Animal tissues, 56 



Interpretation of the Pasteur effect, 

 59 

 Equilibrium schemes, 59 



Inhibition of the Pasteur effect, 62 

 Reversible oxidative inhibition of 

 glycolysis in extracts, 65 

 Thiol influence on fermentation and 

 glycolysis in intact cells, 67 

 Pasteur effect with very low res- 

 piration, 69 

 Conclusion and outlook, 70 



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