32 A SYMPOSIUM ON RESPIRATORY ENZYMES 



eflBciency of the cytochrome oxidase system becomes a limiting 

 factor. 



By this time I can hear you muttering, "Sheer speculation," and I 

 agree with you. I have, however, labored my point concerning the 

 action of such inhibitors because I believe that until we know more 

 about their mode of action any hypotheses of the existence of other 

 oxidative pathways must also be labeled speculation. I do not wish 

 to imply that other unknown pathways do not exist. I heartily agree 

 that they may. I only beg that, in these days of ever-widening use 

 of such inhibitors, more fundamental investigations be made into 

 their mode of action before we becloud the issue with false inter- 

 pretations. 



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